Abstract
This study was designed to explore the effects of amiloride, a Na+-H+ exchange (NHE) inhibitor, on vessel stenosis by observing the expression of NHE-1 protein in vascular smooth muscle (VSM) after balloon injury and the effects of amiloride on VSM cell proliferation, migration, and excretion of extracellular matrices (ECMs). A total of 32 adult male New Zealand white rabbits were randomly divided into a balloon injury group (BG), an amiloride-treated group (AG), and a sham-operated group (SG). The left iliac artery was injured by inflating a 2.5 mm x 20 mm Foley catheter in BG and AG rabbits; in SG rabbits, the Foley catheter was inserted but not inflated. Amiloride (5 mg x kg(-1) x d(-1)) was injected intraperitoneally in AG and the same volume of distilled water was used in BG 3 days before balloon injury and for 28 days after the injury. The left iliac artery was stained by hematoxylin-eosin, alpha-actin, and Masson's trichrome to observe the vessel cava, neointima, media layer, and ECMs. NHE-1 proteins of the VSM were detected by Western blotting. A narrowing of the arterial cava, neointima formation, and thickened VSM layer were observed 28 days after balloon injury in BG and AG. However, in AG, the vessel cava was not as...Continue Reading
References
Jan 1, 1992·Annual Review of Physiology·J Pouysségur, K Seuwen
Mar 1, 1992·Clinical and Experimental Pharmacology & Physiology·H InaribaT Takeda
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S WakabayashiJ Pouysségur
Mar 11, 1991·The American Journal of Physiology·A BobikS Grinpukel
Feb 9, 1990·Science·C SardetJ Pouysségur
Jun 1, 1989·Circulation·M W LiuS B King
Jan 27, 1989·Cell·C SardetJ Pouysségur
Mar 1, 1989·The Journal of Clinical Investigation·B C BerkR W Alexander
Sep 1, 1987·Journal of Cellular Physiology·N Faucher, P H Naccache
Jun 1, 1988·Journal of Molecular and Cellular Cardiology·U IkedaS Hosoda
Oct 1, 1995·The Journal of Clinical Investigation·C BilatoM T Crow
Jan 1, 1995·Kidney International·M S LaPointeD C Batlle
Jun 1, 1995·Circulation·T AsaharaJ M Isner
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·S TakewakiY Yazaki
Feb 15, 1995·Circulation·R R PaulyM T Crow
Jul 1, 1993·Circulation·R H Mohiaddin, D B Longmore
Aug 1, 1993·Circulation Research·R KranzhöferW Kübler
Aug 1, 1993·Circulation Research·M MitsukaB C Berk
Jan 1, 1993·Circulation·D M EichM L Hess
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·R A GottliebB M Babior
Jun 1, 1997·Journal of the American College of Cardiology·N M CapliceM J West
Nov 5, 1997·Progress in Cardiovascular Diseases·D W Muller
Dec 24, 1997·Circulation Research·J M PylesL P Adam
Mar 20, 1999·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E A HausnerA Slee
May 26, 1999·Cardiovascular Research·M R Bennett
Jan 11, 2000·Circulation Research·K Jandeleit-DahmP J Little
Oct 18, 2001·Molecular and Cellular Biology·A R KhaledS K Durum
Mar 30, 2002·Cardiovascular Research·María C Camilión de HurtadoHoracio E Cingolani
Dec 31, 2002·Journal of the American College of Cardiology·Ick-Mo ChungThomas N Wight
Feb 8, 2003·Hypertension·Horacio E CingolaniMaría C Camilión de Hurtado
Mar 8, 2003·Hypertension·Genro FujisawaShun Ishibashi
May 7, 2003·Hypertension·Irene L EnnisHoracio E Cingolani
Jun 7, 2003·The Journal of Biological Chemistry·Robert S HaworthMetin Avkiran
Dec 29, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Egidijus KevelaitisPhilippe Menasché
Aug 16, 2008·Biochemical and Biophysical Research Communications·Shujin WuLiying Liu