The effects of AMPA-induced lesions of the septo-hippocampal cholinergic projection on aversive conditioning to explicit and contextual cues and spatial learning in the water maze

The European Journal of Neuroscience
G M McAlonanB J Everitt

Abstract

The environmental context of an animal both subsumes and is associated with the explicit cues that guide its behavioural responses. Recent work in this laboratory suggests that learning about the relationship between the cues which comprise a context depends on the hippocampus. In the present study the role of the cholinergic input to the hippocampus in contextual learning was assessed in rats using a conditioned stimulus/context conditioning paradigm and spatial learning in the Morris water maze. In the former, a place preference apparatus provided the context. The subject was confined in the black chamber and a 'clicker' conditioned stimulus was presented five times in a 20 min period. A trace interval of 5 or 30 s, depending on the group, was interposed between the end of the clicker and a footshock. Theory predicts that animals in the 5 s condition will learn more about the clicker as a predictor of shock and become strongly conditioned, while those in the 30 s condition learn relatively more about the context. Conditioning to the clicker (conditioned stimulus) was measured in a separate lick suppression chamber--presentation of the clicker suppresses drinking, and contextual learning was determined by recording the time sp...Continue Reading

References

May 1, 1975·The Quarterly Journal of Experimental Psychology·F J Odling-Smee
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
May 1, 1992·Science·J J Kim, M S Fanselow
Feb 14, 1992·Brain Research·M W DeckerD J Anderson
Apr 1, 1992·Current Opinion in Neurobiology·J E LeDoux
Aug 1, 1991·Behavioral Neuroscience·M Good, R C Honey
Sep 1, 1990·Behavioral and Neural Biology·C Castellano, J L McGaugh
Mar 1, 1990·The Journal of Comparative Neurology·R P GaykemaJ Traber
Apr 1, 1989·Behavioural Brain Research·R J Sutherland, A J Rodriguez
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·C Castellano, F Pavone
Jan 1, 1989·Experimental Brain Research·D Gaffan, S Harrison
Jan 12, 1988·Brain Research·K KrnjevićJ Casullo
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 1, 1987·Neurobiology of Aging·E Buchweitz-Milton, H R Weiss
Jan 1, 1984·Progress in Neurobiology·G Buzsáki
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Feb 1, 1954·The Journal of Comparative Neurology·G B KOELLE
Aug 15, 1979·The Journal of Comparative Neurology·L W Swanson, W M Cowan

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Citations

Sep 24, 1999·Hippocampus·M D McEchron, J F Disterhoft
Jan 23, 1999·Biological Psychiatry·J I FriedmanK L Davis
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Olivia LehmannJean-Christophe Cassel
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·M P McDonald, J B Overmier
Jul 1, 1997·Experimental Gerontology·G W BennettK C Fone
Jul 27, 2001·Journal of Chemical Neuroanatomy·T M Hyde, J M Crook
Oct 28, 2004·Behavioral Neuroscience·D M BannermanJ N P Rawlins
Jan 1, 1997·Annual Review of Psychology·B J Everitt, T W Robbins
Sep 24, 2013·Neurobiology of Learning and Memory·Janine L KwapisFred J Helmstetter
Aug 6, 2010·Neurobiology of Learning and Memory·Min-Hee PangJune-Seek Choi
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Jun 10, 1998·Neurobiology of Learning and Memory·C Brandner, F Schenk
May 20, 2019·Journal of Alzheimer's Disease : JAD·Philippos KoulousakisThibaut Sesia
Dec 8, 2004·The European Journal of Neuroscience·Zachariah JonassonMark G Baxter

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