The effects of amphetamine exposure on outcome-selective Pavlovian-instrumental transfer in rats.

Psychopharmacology
Michael W Shiflett

Abstract

Repeated exposure to psychostimulants alters behavioral responses to reward-related cues; however, the motivational underpinnings of this effect have not been fully characterized. The following study was designed to examine how amphetamine sensitization affects performance in rats on a series of Pavlovian and operant tasks that distinguish between general-incentive and outcome-selective forms of conditioned responses. Adult male rats underwent Pavlovian and instrumental training for food pellet rewards. Following training, rats were sensitized to D-amphetamine (2 mg/kg for 7 days). Rats were subsequently tested on an outcome-selective Pavlovian-instrumental transfer (PIT) task, an outcome-reinstatement task, and an outcome devaluation task. Additionally, in a separate experiment, PIT was assessed in amphetamine-sensitized and control rats using a Pavlovian backward-conditioned stimulus. Repeated amphetamine exposure sensitized locomotor activity to acute amphetamine challenge. Amphetamine altered responses to CS presentations by increasing conditioned approach. During tests of PIT, amphetamine-treated rats showed no outcome-selectivity in their responding, responding to a CS whether or not it shared a common outcome with the in...Continue Reading

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Citations

Nov 7, 2012·Annals of the New York Academy of Sciences·Lee HogarthSimon Killcross
Feb 27, 2013·Neuroscience and Biobehavioral Reviews·Benjamin T Saunders, Terry E Robinson
Jul 11, 2014·Behaviour Research and Therapy·Lee HogarthMatt Field
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Nov 11, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Y Vandaele, S H Ahmed

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