Abstract
1. We measured the ability of glucagon and amrinone, used alone and in combination, to improve the myocardial function in a rat isolated heart model of calcium channel blocker (CCB) cardiotoxicity. 2. Verapamil 10(-4) mol consistently decreased heart rate and cardiac contractile force in our Langendorff rat isolated heart preparations. Glucagon increased the heart rate in a dose-dependent fashion. Amrinone increased the heart rate only at the 1 x 10(-1) mol concentration, and had no significant effect on cardiac contractility. 3. A positive linear correlation was found between the glucagon concentration and the percent recovery of baseline contractile force. 4. Although complete reversal of verapamil-induced myocardial depression occurred at glucagon concentrations of > 3 x 10(-6) mol, amrinone produced only 23.8 +/- 3.6% recovery from baseline at its highest concentration (4 x 10(-3) mol). 5. When glucagon and amrinone were administered together, there was no additional increase over glucagon alone in the increase in contractile force. 6. Glucagon, and not amrinone, is an appropriate agent, capable of reversing verapamil-induced myocardial toxicity in this rat isolated heart model. In vivo studies should be performed to assess...Continue Reading
References
Sep 1, 1992·British Journal of Pharmacology·H DongS X Peng
Sep 1, 1992·The American Journal of Emergency Medicine·T L LitovitzB F Schmitz
Dec 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·M Shahid, C D Nicholson
Sep 1, 1991·The American Journal of Emergency Medicine·T L LitovitzW Klein-Schwartz
Jun 1, 1989·Journal of Cardiovascular Pharmacology·C J FrangakisA E Farah
Nov 1, 1989·The American Journal of Emergency Medicine·B Z Horowitz, K J Rhee
Sep 1, 1989·Canadian Journal of Physiology and Pharmacology·E DagherC Chartrand
Jul 1, 1988·European Heart Journal·G KisslingR Jacob
Mar 1, 1988·Critical Care Medicine·A L ZaritskyB Chernow
Jan 1, 1987·Pharmacology·S R JollyB R Lucchesi
Jun 1, 1987·Anesthesiology·V H Makela, P A Kapur
Nov 15, 1986·The American Journal of Cardiology·M GoenenJ Bonte
Aug 1, 1985·Cardiovascular Research·A A AlousiD J Fort
Jun 1, 1968·Circulation Research·B R Lucchesi
Oct 23, 1982·Lancet·B J CrumpJ A Vale
Jun 1, 1983·The Journal of Trauma·M K McLeodD S Gann
Oct 1, 1994·British Journal of Pharmacology·J SuL Hittinger
Oct 1, 1994·British Journal of Pharmacology·R OkuyamaT Nagao
Mar 1, 1995·Annals of Emergency Medicine·C K StoneR Carroll
Jul 1, 1994·British Journal of Pharmacology·A F RumpW Klaus
Jul 1, 1993·The American Journal of Emergency Medicine·J N LoveD J Mundt
Nov 1, 1993·The Journal of Pharmacology and Experimental Therapeutics·J A KlineR M Raymond
Feb 1, 1993·Annals of Emergency Medicine·E A RamoskaD Borys
Jul 1, 1993·Annals of Emergency Medicine·L R WolfE J Otten
Citations
Sep 30, 2003·Journal of Toxicology. Clinical Toxicology·Benoit Bailey
Aug 26, 1998·Journal of Toxicology. Clinical Toxicology·Y TuncokH Guven
May 19, 2005·Toxicological Reviews·Christopher R DeWitt, Javier C Waksman
Aug 27, 2005·Human & Experimental Toxicology·D M WoodP I Dargan
Jan 22, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Steven D Salhanick, Michael W Shannon
Jun 29, 2007·Drugs in R&D·Gilles Hanton