PMID: 6406254May 1, 1983Paper

The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats

Experimental Eye Research
R PoulsomH Heath

Abstract

To investigate the aetiology of complications secondary to experimental diabetes in the rat, the concentrations of glucose, sorbitol, fructose, fructose-1-phosphate, lactate and inositol were measured in the retina and sciatic nerve of streptozotocin-diabetic and normal rats treated for 22 days with ICI 105552 (1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid, sodium salt; 50 mg/kg body wt daily), an inhibitor of aldose reductase (E.C. 1.1.1.21) the first enzyme of the sorbitol pathway. In the diabetic nerve, where accumulation of sorbitol may be pathogenic, treatment with ICI 105552 reduced the accumulations of sorbitol (70%), fructose (47%) and lactate (34%) without affecting glucose, fructose-1-phosphate or inositol. In the nerves of controls, the inhibitor reduced both sorbitol (23%) and fructose (20%) levels without other effects. In the diabetic retina where accumulation of sorbitol or lactate might be pathogenic, treatment with ICI 105552 had no statistically significant effect upon the concentrations of glucose, sorbitol, fructose, fructose-1-phosphate or inositol. However, the inhibitor reduced the concentration of lactate to below the non-diabetic level. In the retinas of controls, dosage with I...Continue Reading

References

Aug 1, 1976·Diabetologia·D PapachristodoulouS S Kang
Feb 23, 1977·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·G Imre
Jun 1, 1979·Diabetes·R S Clements
Apr 1, 1974·The Australian Journal of Experimental Biology and Medical Science·J C HuttonF C Hollows
Sep 17, 1968·Biochimica Et Biophysica Acta·R M Broekhuyse
May 1, 1983·Biochemical Pharmacology·R Poulsom, H Heath
Aug 1, 1954·The Journal of Clinical Investigation·W H DAUGHADAYE HOUGHTON

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Citations

Mar 1, 1991·Diabetes/metabolism Reviews·G PuglieseJ R Williamson
Jan 1, 1992·Pharmacology & Therapeutics·D R TomlinsonA L Carrington
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B I Gaynes, J B Watkins
Apr 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·D R Tomlinson
May 1, 1987·Metabolism: Clinical and Experimental·B W GriffinB M York
Jul 1, 1990·The Journal of Diabetic Complications·D StriblingJ C Smith
Mar 1, 1987·Current Eye Research·R Poulsom
Oct 1, 1992·Metabolism: Clinical and Experimental·A KashiwagiY Saeki
Jan 1, 1989·The Journal of Diabetic Complications·H E HarrisonC M Perkins

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