The effects of anaesthesia on the developing brain: a summary of the clinical evidence

F1000Research
Clara Ky YuMichael G Irwin

Abstract

There is data amassing in the literature regarding the potentially adverse effects of anaesthesia exposure on the developing human brain. The purpose of this article is to summarise current relevant data from clinical studies in this area. Articles from journals written in English were searched for using PubMed, Ovid and Medline. Keywords used included: brain (newborn, infant, child and neonate), neurodegeneration, apoptosis, toxicity, neurocognitive impairment (developmental impairment and learning disorders) and anaesthesia (intravenous, inhalational and sedation). From the initial search, 23 articles were identified as potentially relevant, with publication dates spanning from 1978 to 2012.  Twelve studies were deemed irrelevant to the research questions. The results of neurocognitive assessment from eight of the remaining eleven studies had showed some differences in the performances of children exposed to anaesthesia. The control population in these studies was highly variable. The age at which the subjects were exposed to anaesthesia ranged from prenatal to 4 years in the majority of studies with one including children aged up to 12 years when exposed. Although there is clinical data suggesting a possible detrimental effe...Continue Reading

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Citations

Jul 12, 2016·Paediatric Anaesthesia·Mahtab Poor Zamany Nejat KermanyEsmail Riahi
Jun 28, 2017·The Journal of Laryngology and Otology·M GruberM Neeff
Nov 22, 2015·Pediatric Radiology·Lynda FlomRachel P Berger
Aug 1, 2015·Pediatric Radiology·Brett J MollardJonathan R Dillman
Jan 7, 2020·Pediatric Radiology·Rachel P BergerAshok Panigrahy
Sep 23, 2021·Pediatric Radiology·Sarah J MenasheRamesh S Iyer

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