PMID: 3746696May 1, 1986Paper

The effects of anaesthetics and high pressure on the responses of the rat superior cervical ganglion in vitro

The Journal of Physiology
H J Little, D L Thomas

Abstract

The effects of helium pressure and of general anaesthetics were studied on the responses of the isolated superior cervical ganglion of the rat, to determine how far these reflected the pressure reversal of anaesthesia seen in vivo. The method of Brown & Marsh (1974) for extracellular recording of surface potentials was adapted for use in a high-pressure chamber. Helium alone, at 130 atm, did not alter the responses of the ganglion to gamma-aminobutyric acid (GABA) but significantly depressed the depolarizing and hyperpolarizing components of the nicotinic responses, and the muscarinic responses. The potentiation of the responses to GABA caused by pentobarbitone was not altered by the application of helium, at 130 atm. This pressure also decreased further the nicotinic responses which were depressed by pentobarbitone. Nitrogen, at 34 atm (the anaesthetic ED50 in vivo) and at 68 atm, significantly decreased the nicotinic responses of the ganglia, and the addition of helium to a total of 130 atm further increased this depression. At pressures of 3.3-68 atm, nitrogen caused small decreases in the responses to GABA. Nitrous oxide at 1.5 atm (the ED50 for loss of righting reflex in mice) and at 3 atm, significantly depressed the resp...Continue Reading

Citations

Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·O DarbinJ C Rostain
Aug 26, 2010·British Journal of Pharmacology·P-L Chau
Apr 18, 1998·Nature Medicine·V Jevtović-TodorovićJ W Olney
Dec 3, 1998·Alcoholism, Clinical and Experimental Research·D L Davies, R L Alkana

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