PMID: 6413882Jul 1, 1983Paper

The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice

Neuropharmacology
P E KeaneM Morre

Abstract

The effect of valproic acid and 10 close analogues (7 branched and 3 non-branched) were studied on the content of gamma-aminobutyric acid (GABA) in brain and on seizures induced by pentylenetetrazol (PTZ) in mice. All 8 branched fatty acids protected against seizures induced by pentylenetetrazol, but the 3 non-branched acids were inactive. A significant correlation was observed between side-chain length and anticonvulsant potency. However, sedative and toxic phenomena became apparent with longer chain lengths. The 3 non-branched fatty acids did not alter levels of GABA in brain, but there was a significant correlation between anticonvulsant activity and increased brain GABA levels, for the 8 branched fatty acids. Despite this correlation, one branched analogue, 2-ethylbutyric acid, possessed anticonvulsant activity but did not increase the content of GABA in brain.

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Citations

Jul 18, 2009·Journal of Molecular Modeling·Nieves C ComelliAlicia H Jubert
Jan 25, 1990·European Journal of Pharmacology·K A Smith, G G Bierkamper
Jan 1, 1988·Progress in Neurobiology·K T Wann, A G Macdonald
Jul 15, 1998·Molecular and Biochemical Parasitology·K L BlairD P Thompson
Jan 1, 1984·Epilepsia·M MorreR Roncucci
Oct 2, 2013·Journal of Inorganic Biochemistry·Manuela AlessioDomenico Osella
Jun 24, 2004·Bioorganic & Medicinal Chemistry·Silvina M TassoGuillermina L Estiú
Nov 28, 2012·Neuropharmacology·Pishan ChangRobin S B Williams
Dec 1, 1993·Journal of Pharmaceutical Sciences·M M ElmazarH Nau
Sep 17, 2009·Biochemical Society Transactions·Nicole Terbach, Robin S B Williams
Nov 13, 2007·Journal of Medicinal Chemistry·Jakob Avi ShimshoniBoris Yagen

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