The effects of androgen deprivation therapy with weight management on serum aP2 and adiponectin levels in prostate cancer patients

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
Hayato UrushimaKazuhisa Maeda

Abstract

Androgen deprivation therapy (ADT) for the treatment of prostate cancer (PCa) causes an increase in total body fat, leading to a net gain in body weight. Moreover, the use of the luteinizing hormone-releasing hormone agonists in ADT causes a decrease in serum androgen levels, leading to the development of metabolic syndrome (MetS). Androgen blockade significantly increases plasma adiponectin levels, which has some efficacy against MetS, whereas ADT increases fasting plasma insulin and decreases insulin sensitivity, suggesting that there are other mechanisms involved in the onset of MetS besides adiponectin activation. We investigated the effects of ADT on serum aP2 and adiponectin in PCa patients. Six months post-ADT, serum aP2 and adiponectin levels were significantly increased, although there were no changes in patient body weight and no correlation between the changes in serum aP2 and total adiponectin levels. The serum adiponectin and aP2 levels have independent implications in ADT for PCa; therefore, their combined measurement will clarify the impact on the development of obesity-related diseases during ADT. Contrary to adiponectin, high serum aP2 levels were correlated with the late development of MetS. Further studies ar...Continue Reading

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Citations

Nov 23, 2015·Reviews in Endocrine & Metabolic Disorders·Abdulmaged M Traish, Michael Zitzmann
Aug 23, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jae Hyun RyuTag Keun Yoo
Oct 17, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Safa Ali Ahmed AmarCanan Demir
Mar 30, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Yasin CeylanTansu Degirmenci
Jan 22, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Daisuke WatanabeAkio Mizushima
May 23, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Erdem AkbayCuma Aytekin
Nov 14, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Karli SreenivasuluCleetus Cherupanakkal
Oct 26, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·M F DuarteJ M La Fuente

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