PMID: 3755688Aug 1, 1986Paper

The effects of androgen on the transcription of specific genes in guinea pig seminal vesicle epithelium

Molecular and Cellular Endocrinology
J T MooreE D Wieben

Abstract

Steroid hormones have been shown to have highly differential effects on the expression of abundant cell-specific protein genes in a multitude of model tissues. In rat seminal vesicle, for example, DNA clones representing two major secretory protein genes have been used to show that both of the genes are differentially regulated by androgen. In this paper, we have examined the effects of androgen on the transcription of two major secretory protein genes in guinea pig seminal vesicle epithelium. Nuclear run-off experiments were used to show that castration of the adult resulted in a 3-fold decrease in total transcription activity. Surprisingly, the decrease in total transcriptional activity was not reflected in a differential decrease in the transcriptional activity of the two major secretory protein genes. When the effects of castration on the transcriptional activity of the major secretory protein genes were compared to the effects on other genes, it was found that the transcriptional activity of each gene examined was decreased by the same magnitude as the major secretory protein genes. Similarly, the transcriptional activity of every gene examined increased by the same magnitude as the major secretory protein genes during hor...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M G Parker, G T Scrace
Mar 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·M EpperlyC M Veneziale
Aug 1, 1964·The Biochemical Journal·C C Widnell, J R Tata
Feb 10, 1984·Nucleic Acids Research·M Groudine, C Casimir
May 25, 1983·Nucleic Acids Research·J C KandalaW S Kistler
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P K ElderM J Getz
Mar 1, 1984·Journal of Steroid Biochemistry·M EpperlyC M Veneziale
Jan 1, 1985·Plant Molecular Biology·D A Wakarchuk, R I Hamilton

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Citations

Apr 1, 1991·Molecular and Cellular Endocrinology·S J Higgins, A L Hemingway
Sep 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·N B WestR M Brenner
Aug 1, 1995·The Journal of Experimental Zoology·R CarballadaP Esponda

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