Mar 24, 2020

The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts

Sexual Medicine
Omer Faruk KirlangicSerap Gur

Abstract

Cardiometabolic syndrome (CMS), as a bunch of metabolic disorders mainly characterized by type 2 diabetes mellitus (T2DM), hypertension, atherosclerosis, central adiposity, and abdominal obesity triggering androgen deficiency, is one of the most critical threats to men. Although many significant preclinical and clinical findings explain CMS, new approaches toward common pathophysiological mechanisms and reasonable therapeutic targets are lacking. To gain a further understanding of the role of androgen levels in various facets of CMS such as the constellation of cardiometabolic risk factors including central adiposity, dyslipidemia, insulin resistance, diabetes, and arterial hypertension and to define future directions for development of effective therapeutic modalities. Clinical and experimental data were searched through scientific literature databases (PubMed) from 2009 to October 2019. Evidence from basic and clinical research was gathered with regard to the causal impact and therapeutic roles of androgens on CMS. There are important mechanisms implicated in androgen levels and the risk of CMS. Low testosterone levels have many signs and symptoms on cardiometabolic and glycometabolic risks as well as abdominal obesity in men...Continue Reading

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Mentioned in this Paper

Dyslipidemias
Clinical Management
Androgens
Direction
Structure of Articular Surface of Bone
Insulin Resistance
Diabetes
Obesity
Testosterone
Metabolic Diseases

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