PMID: 2492407Feb 1, 1989Paper

The effects of anesthetics and PaCO2 on the cerebrovascular, metabolic, and electroencephalographic responses to nitrous oxide in the rabbit

Anesthesia and Analgesia
R KaiedaD S Warner

Abstract

The effects of nitrous oxide (N2O) on cerebral blood flow and metabolism, intracranial pressure (ICP), the electroencephalogram etc. has been well described, at least when N2O is used alone. However, during neurosurgical procedures, N2O is almost always given in combination with either volatile or intravenous agents, and generally after the institution of some degree of hypocarbia. Unfortunately, the modifying influence of such interventions are not well known, and, therefore, the cerebral effects of 70% N2O were studied in rabbits anesthetized with either 1 MAC halothane or isoflurane, or with a fentanyl/pentobarbital combination, during both normocarbia (PaCO2 approximately 40 mm Hg) and hypocarbia (PaCO2 approximately 20 mm Hg). Cortical cerebral blood flow (CBFc) and sagittal sinus blood flow (CBFss--as an index of "global" forebrain flow) were measured using the hydrogen clearance method. Cerebral oxygen consumption (CMRO2) was calculated, and intracranial pressure (ICP), central venous pressure, heart rate, mean arterial pressure, and the EEG were also recorded. CBFc during normocarbic halothane, isoflurane, and fentanyl-pentobarbital anesthesia was 69 +/- 23, 41 +/- 16, 53 +/- 26 ml.100g-1.min-1 (mean +/- SD) respectivel...Continue Reading

Citations

Nov 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J E Leon, B Bissonnette
Jan 1, 1992·Acta Anaesthesiologica Scandinavica·L AlgotssonT Holmin
Aug 21, 2001·CNS Drugs·P Ravussin, O Wilder-Smith
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G L LudbrookD F Gorman
May 30, 1998·Anesthesiology·J E Brian
Aug 1, 1996·Anesthesia and Analgesia·F E GyulaiP M Winter
Oct 4, 2006·Current Opinion in Anaesthesiology·P Amorim
Jan 8, 2008·Neurosurgery·Chad D ColeWilliam T Couldwell

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