The effects of anodal transcranial direct current stimulation and patterned electrical stimulation on spinal inhibitory interneurons and motor function in patients with spinal cord injury

Experimental Brain Research
Tomofumi YamaguchiMeigen Liu

Abstract

Supraspinal excitability and sensory input may play an important role for the modulation of spinal inhibitory interneurons and functional recovery among patients with incomplete spinal cord injury (SCI). Here, we investigated the effects of anodal transcranial direct current stimulation (tDCS) combined with patterned electrical stimulation (PES) on spinal inhibitory interneurons in patients with chronic incomplete SCI and in healthy individuals. Eleven patients with incomplete SCI and ten healthy adults participated in a single-masked, sham-controlled crossover study. PES involved stimulating the common peroneal nerve with a train of ten 100 Hz pulses every 2 s for 20 min. Anodal tDCS (1 mA) was simultaneously applied to the primary motor cortex that controls the tibialis anterior muscle. We measured reciprocal inhibition and presynaptic inhibition of a soleus H-reflex by stimulating the common peroneal nerve prior to tibial nerve stimulation, which elicits the H-reflex. The inhibition was assessed before, immediately after, 10 min after and 20 min after the stimulation. Compared with baseline, simultaneous application of anodal tDCS with PES significantly increased changes in disynaptic reciprocal inhibition and long-latency p...Continue Reading

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Citations

Nov 16, 2019·Experimental Brain Research·Ryo HirabayashiHideaki Onishi
Jun 9, 2020·The European Journal of Neuroscience·Ryo HirabayashiHideaki Onishi
Jan 13, 2018·Neural Regeneration Research·Aysegul GunduzHatice Kumru
Jul 28, 2020·Frontiers in Neurology·Lynsey D Duffell, Nicholas de Neufvillle Donaldson
Mar 12, 2017·Restorative Neurology and Neuroscience·Fabiana Tenório Gomes da SilvaFelipe Fregni
Aug 30, 2017·Frontiers in Neurology·Paola MarangoloAlberto Priori
Jan 20, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hideto NakayamaEiji Shimizu
Jun 17, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marcel SimisFelipe Fregni
Nov 13, 2021·Current Opinion in Neurology·Jennifer A IddingsEdelle C Field-Fote

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