PMID: 8954755Dec 1, 1996Paper

The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
B L UphamJ E Trosko

Abstract

Polycyclic aromatic hydrocarbons (PAHs), many of which are known carcinogens, are derived from the pyrolysis of organic materials. A rich source of PAHs is cigarette smoke, which contains methylated anthracenes and phenanthrenes as the predominant PAHs. The tumor-promoting activity of cigarette smoke has been well documented. The down-regulation of gap junction intercellular communication (GJIC) by nongenotoxic chemicals and several oncogenes has been implicated in tumor promotion. Therefore, we determined the effects of the three isomers of methylanthracene on GJIC in WB-F344 rat liver epithelial cells. Anthracene and 2-methylanthracene did not significantly inhibit GJIC, whereas anthracene methylated in the 1 or 9 position reversibly inhibited GJIC with I50 values of 22 and 36 microM, respectively. Inhibition occurred within 15 min. In conclusion, the biological effect of methylanthracene depends on the ring position of the methyl group, and these inhibitory isomers could play a potential role in tumor promotion of methylated PAH-rich mixtures such as cigarette smoke and crude oil products.

Citations

Jun 13, 2002·Environmental Health Perspectives·Carl-Elis BoströmRoger Westerholm
Mar 25, 2010·World Journal of Gastroenterology : WJG·Shu-Yu TaiMing-Tsang Wu
Jul 3, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jiguo WuChongyu Lan
Dec 3, 2014·Toxicology and Applied Pharmacology·Shanthi GanesanAileen F Keating
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Erica D BruceThomas J McDonald
May 2, 2001·Environmental Science & Technology·W R ReevesK C Donnelly
May 25, 2011·Chemical Research in Toxicology·Lenka TrilecováMiroslav Machala
Aug 28, 2021·International Journal of Molecular Sciences·Iva SovadinováPavel Babica
Mar 29, 2002·Environmental Science & Technology·S L Luster-TeasleyS J Masten

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