The effects of anti-CD4 and anti-CD8 antibody treatment on placental growth and function in allogeneic and syngeneic murine pregnancy

Cellular Immunology
I AthanassakisT G Wegmann

Abstract

During pregnancy, maternal immune recognition of paternal alloantigens has been shown to result in an increased influx of maternal T cells into the spleen, draining lymph nodes and decidua. In previous studies we have shown that polyclonal or monoclonal anti-T cell antibody treatment of allogeneically pregnant mice results in decreased placental proliferation and phagocytosis in vivo. In the present study we compare the effect of such antibody treatment during allogeneic and syngeneic pregnancy. We show that monoclonal anti-CD8 treatment of both types of pregnant females reduces placental proliferation and phagocytosis. Anti-CD4 antibody treatment, on the other hand, only affects placental proliferation, indicating that there is a complex network of immune interactions affecting placental growth and function.

References


❮ Previous
Next ❯

Citations

May 1, 1993·Journal of Reproductive Immunology·G C DouglasB F King
Jul 1, 1996·Immunology Letters·L N RubenR E Clothier
Oct 1, 1991·Current Opinion in Immunology·J W Pollard
Oct 1, 1992·Current Opinion in Immunology·S A RobertsonR F Seamark
Feb 1, 1993·Immunology and Cell Biology·L GuilbertT G Wegmann
Jan 1, 1993·American Journal of Reproductive Immunology : AJRI·T MoriiN Narita
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·R Raghupathy, S Tangri
Jul 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·A Amarante-PaffaroE Bevilacqua
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Gérard ChaouatNathalie Ledée
Feb 28, 2015·Journal of Reproductive Immunology·Mona RahmatiNathalie Ledee
Nov 1, 2007·Expert Review of Clinical Immunology·Gérard Chaouat
Feb 20, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Mohamed BalahaYahya Makkeyia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.