PMID: 8959247Dec 10, 1996Paper

The effects of antineoplastic chemotherapy on HIV disease

AIDS Research and Human Retroviruses
Stefania ZanussiPaolo De Paoli

Abstract

Six patients with human immunodeficiency virus (HIV)-associated non-Hodgkin lymphoma receiving chemotherapy (CT) with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus granulocyte colony-stimulating factor were sequentially monitored to study the effects of these treatments on their immunologic status (CD4 and CD8 cell counts) and on HIV plasma viremia. We show that mean CD4 cell counts declined significantly after the third cycle of CT (187 +/- 117/microliters before CT versus 92.4 +/- 60/microliters; p = 0.04) and remained significantly reduced 4 months after completion of CT. Modifications of CD8 cell counts were not statistically significant. The effects of CT on plasma viremia, as measured by a competitive polymerase chain reaction technique, were delayed until the fourth cycle, when an increase of viral load ranging from 0.6 to 2 logs (p = 0.027) was observed. After this point, viremia returned to baseline levels, with the exception of two patients who later developed opportunistic infections and one who underwent disease progression. These results suggest that, contrary to CD4 cell counts, plasma viremia could be a faithful surrogate marker for monitoring of HIV disease progression in patients underg...Continue Reading

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Citations

Apr 12, 2001·British Journal of Haematology·M Bower
Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cecilia SimonelliUmberto Tirelli
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emanuela VaccherUmberto Tirelli
Aug 15, 1997·The Journal of Clinical Investigation·M ComarM Giacca
Aug 4, 2009·Expert Opinion on Biological Therapy·Thomas Newsom-DavisMark Bower
Aug 4, 2007·Cancer Treatment and Research·Anita AroraStephen K Tyring
Aug 27, 2014·Journal of Medical Virology·Andrew M MusyokiM Jeffrey Mphahlele
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark BowerChristina Thirlwell
Dec 7, 2002·Best Practice & Research. Clinical Haematology·Mark Bower

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