The effects of antiplatelet agents on platelet-leukocyte aggregations in patients with acute cerebral infarction

Journal of Thrombosis and Thrombolysis
Yong-Jun CaoChun-Feng Liu

Abstract

Studies have shown that platelet-leukocyte aggregates (PLA) are sensitive to platelet activation which might exist before the onset of cerebral infarction. In this study, we investigated the formation of PLA in patients with cerebral infarction and the effects of antiplatelet agents on PLA. The level of soluble P-selectin, C-reaction protein, platelet aggregation rate and leukocyte-platelet aggregations were measured in 40 patients with acute cerebral infarction and 20 normal controls. The 40 patients were randomly assigned to two treatment groups: aspirin group (n = 20) and clopidogrel group (n = 20). Both groups were monitored for Scandinavian stroke scale (SNSS), soluble P-selectin, serum C-reaction protein, platelet aggregation rate and PLA before and after the treatment. Flow cytometry was used to detect the levels of PLA in the blood. The percentage of platelet-monocyte aggregates (PMA) in patients with cerebral infarction was significantly increased compared with the controls (P < 0.001), which was positively correlated to soluble P-selectin, C-reaction protein and platelet aggregation rate (P < 0.05). After the treatment, the levels of PMA and platelet aggregation rate were decreased in both groups (P < 0.05). The level...Continue Reading

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Citations

Oct 3, 2012·Molecular and Cellular Neurosciences·Katie N MurrayStuart M Allan
Feb 5, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Kozue OkanoOsamu Yamada
Feb 4, 2014·The Journal of Allergy and Clinical Immunology·Tanya M LaidlawJoshua A Boyce
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Jul 9, 2021·Frontiers in Cardiovascular Medicine·Gaukhar BaidildinovaPaola E J van der Meijden

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