PMID: 7861447Oct 1, 1994

The effects of arterial blood gas values on lesion volumes in a graded rat spinal cord contusion model

Journal of Neurotrauma
P P Huang, W Young

Abstract

The detrimental effects of extreme blood gas values are well documented. However, the range of normal values has not been rigorously defined. There is an ongoing debate concerning the need for ventilation and tight control of blood gas values in spinal cord injury models. Consequently, we performed a retrospective study of 84 rats using a graded rat spinal cord contusion model. Spinal cord ionic lesion volumes were calculated from Na and K shifts at 24 h after injury. Blood gas measurements were obtained 5 min before contusion. For pH values of 7.31-7.46, systemic acidosis was associated with a small but significant decrease in ionic lesion volumes in the 12.5 and 25 g.cm contusion groups (p < 0.05 and p < 0.03, respectively). pH had no effect on ionic lesion volumes in the 50 g.cm contusion group (p > 0.5). PaCO2 values from 23 to 53 mm Hg showed an effect only at 25 g.cm (p < 0.05). PaO2 values of 46-138 mm Hg and calculated HCO3 values of 13-28 mEq/L had no effect on ionic lesion volumes. Two conclusions may be derived from these data. First, mild systemic acidosis is associated with a small reduction in ionic lesion volumes after mild and moderate injury but not after severe injury. This suggests that secondary mechanisms p...Continue Reading

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Citations

Feb 1, 1997·Journal of Neuroscience Methods·M G Fehlings, R Nashmi
Aug 31, 2001·Journal of Neurotrauma·C D MillsC E Hulsebosch
Apr 5, 2003·Journal of Neurotrauma·Stephen W ScheffJames E Lumpp
Mar 23, 2013·PloS One·Myungsik YooMelitta Schachner
Jul 31, 2001·Experimental Neurology·C D MillsC E Hulsebosch
Jan 5, 2002·Experimental Neurology·Charles D MillsC E Hulsebosch
Feb 11, 2000·Annals of the New York Academy of Sciences·F SalaW Young
Jan 21, 2014·Neuropathology and Applied Neurobiology·E R Burnside, E J Bradbury
Jan 30, 2002·Brain Research·Louis P Vera-PortocarreroK N Westlund
Jun 20, 2008·Reviews in the Neurosciences·Aysha Z AkhtarChad B Sandusky
Mar 28, 2007·Journal of Neuroscience Research·Lisa D CainD J McAdoo
Jan 26, 2005·Journal of Neuroscience Research·O Nesic-TaylorJ R Perez-Polo

Related Concepts

Metabolic Acidosis
Blood Gas Analysis
Carbon Dioxide
Contusions
Hydrogen-Ion Concentration
Dioxygen
August Rats
Regression Analysis
Spinal Cord
Post-Traumatic Myelopathy

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