PMID: 7861447Oct 1, 1994

The effects of arterial blood gas values on lesion volumes in a graded rat spinal cord contusion model

Journal of Neurotrauma
P P Huang, W Young


The detrimental effects of extreme blood gas values are well documented. However, the range of normal values has not been rigorously defined. There is an ongoing debate concerning the need for ventilation and tight control of blood gas values in spinal cord injury models. Consequently, we performed a retrospective study of 84 rats using a graded rat spinal cord contusion model. Spinal cord ionic lesion volumes were calculated from Na and K shifts at 24 h after injury. Blood gas measurements were obtained 5 min before contusion. For pH values of 7.31-7.46, systemic acidosis was associated with a small but significant decrease in ionic lesion volumes in the 12.5 and 25 contusion groups (p < 0.05 and p < 0.03, respectively). pH had no effect on ionic lesion volumes in the 50 contusion group (p > 0.5). PaCO2 values from 23 to 53 mm Hg showed an effect only at 25 (p < 0.05). PaO2 values of 46-138 mm Hg and calculated HCO3 values of 13-28 mEq/L had no effect on ionic lesion volumes. Two conclusions may be derived from these data. First, mild systemic acidosis is associated with a small reduction in ionic lesion volumes after mild and moderate injury but not after severe injury. This suggests that secondary mechanisms p...Continue Reading


Jan 1, 1975·Acta Neuropathologica·I D DuncanA McQueen
Dec 1, 1976·Journal of Neurosurgery·A N Sandler, C H Tator
Jan 1, 1992·Journal of Neurotrauma·S S PanterE D Hall
Jan 1, 1990·Annals of Neurology·S S PanterA I Faden
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·M G Boyeson, D M Feeney
Aug 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S A GoldmanF Plum
Feb 12, 1986·Brain Research·W Young, I Koreh
Apr 1, 1985·Experimental Neurology·J R WrathallF Harvey
Apr 1, 1985·Experimental Neurology·L J Noble, J R Wrathall
Feb 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·I R Griffiths
Feb 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·I R Griffiths
May 1, 1971·Journal of Neurosurgery·G E LockeW E Hunt
Dec 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·N A Lassen
May 1, 1969·The American Journal of Physiology·A L SmithS C Alexander
Oct 1, 1981·Annals of Neurology·A I FadenJ W Holaday
Dec 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M GardinerB K Siesjö
Sep 1, 1961·Experimental Neurology·R L FRIEDE, W H VAN HOUTEN
Aug 1, 1963·Journal of Neurology, Neurosurgery, and Psychiatry·A M HARPER, R A BELL
Sep 1, 1971·Journal of Neurosurgery·D J Fairholm, I M Turnbull


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Apr 5, 2003·Journal of Neurotrauma·Stephen W ScheffJames E Lumpp
Mar 23, 2013·PloS One·Myungsik YooMelitta Schachner
Jul 31, 2001·Experimental Neurology·C D MillsC E Hulsebosch
Jan 5, 2002·Experimental Neurology·Charles D MillsC E Hulsebosch
Feb 11, 2000·Annals of the New York Academy of Sciences·F SalaW Young
Jan 21, 2014·Neuropathology and Applied Neurobiology·E R Burnside, E J Bradbury
Jan 30, 2002·Brain Research·Louis P Vera-PortocarreroK N Westlund
Jun 20, 2008·Reviews in the Neurosciences·Aysha Z AkhtarChad B Sandusky
Mar 28, 2007·Journal of Neuroscience Research·Lisa D CainD J McAdoo
Jan 26, 2005·Journal of Neuroscience Research·O Nesic-TaylorJ R Perez-Polo

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