The effects of atmospheric hydrogen sulfide on peripheral blood lymphocytes of chickens: Perspectives on inflammation, oxidative stress and energy metabolism

Environmental Research
Qianru ChiShu Li

Abstract

Excessive hydrogen sulfide (H2S) affects poultry health. Exposure to air pollution induces inflammation, oxidative stress, energy metabolism dysfunction and adverse health effects. However, few detailed studies have been conducted on the molecular mechanisms of H2S-induced injury in poultry. To understand how H2S drives its adverse effects on chickens, twenty-four 14-day-old chickens were randomly divided into two groups. The chickens in the control group were raised in a separate chamber without H2S, and the chickens in the treatment group were exposed to 30 ppm H2S. After 14 days of exposure, peripheral blood samples were taken and the lymphocytes were extracted to detect inflammation, oxidative stress and energy metabolism in broilers. Overall, an increase in the inflammatory response was detected in the peripheral blood lymphocytes following H2S exposure compared to the control group, and the expression levels of the heat shock proteins (HSPs) and the transcription factors nuclear factor κB (NF-κB), cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) were up-regulated in the H2S group, which further suggested that H2S induced an inflammatory response via the NF-κB pathway. Because of the activation of NF-κB,...Continue Reading

Citations

Jun 21, 2019·Biological Trace Element Research·Jianwen XuZiwei Zhang
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Yiming ZhangShu Li
Jun 26, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Lin ZhuWu Duan
Jul 9, 2020·Animals : an Open Access Journal From MDPI·Tanja HofmannVolker Stefanski
Apr 25, 2020·Environmental Science and Pollution Research International·Yue WangJianzhu Liu
Feb 3, 2021·Antioxidants·Peter F SuraiMichael T Kidd

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