The effects of axotomy and preganglionic denervation on the expression of pituitary adenylate cyclase activating peptide (PACAP), galanin and PACAP type 1 receptors in the rat superior cervical ganglion

Brain Research
K MollerF Sundler

Abstract

The effects of axotomy, chemical sympathectomy and preganglionic denervation on the expression of the neuropeptides, pituitary adenylate cyclase-activating peptide (PACAP), galanin (GAL), and the PACAP type 1 receptor in the rat superior cervical ganglion (SCG) were investigated by immunocytochemistry, in situ hybridization and receptor autoradiography. An antibody recognizing the rat vesicular acetylcholine transporter (VAChT) was used for the detection of preganglionic cholinergic fibers. In the normal SCG, PACAP-immunoreactivity (-IR) was present in numerous, basket-forming, preganglionic nerve fibers, while very few SCG neurons expressed PACAP. GAL-IR was restricted to occasional neurons, and a few nerve fibers, most of which were, in addition, PACAP-IR. PACAP type 1 receptors were expressed in all nerve cell bodies. Axotomy resulted in a rapid and prominent upregulation of PACAP in a large number of nerve cell bodies. There was a large increase also in GAL expression in many nerve cell bodies. In contrast, there was a marked decline in PACAP type 1 receptor expression. Chemical sympathectomy by administration of the catcholaminergic neurotoxin, 6-hydroxydopamine (6-OHDA), gave rise to similar changes. Preganglionic denerva...Continue Reading

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Citations

Apr 22, 2010·Journal of Molecular Neuroscience : MN·Beatrice M GirardRodney L Parsons
May 8, 2010·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Apr 25, 2012·Journal of Molecular Neuroscience : MN·D ReglodiA Tamas
May 16, 2012·Journal of Molecular Neuroscience : MN·Beatrice M GirardRodney L Parsons
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 3, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen M BraasMargaret A Vizzard
Sep 4, 2012·International Journal of Molecular Sciences·Andrea TamasPeter Bukovics
Mar 23, 2013·British Journal of Pharmacology·J A Waschek
Jan 25, 2006·Molecular and Cellular Neurosciences·Phyllis C Pugh, Joseph F Margiotta
Feb 2, 2006·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Marcin Bartłomiej Arciszewski, Krzysztof Wasowicz
Apr 16, 2004·Journal of Neurobiology·Kristen L BoeshoreRichard E Zigmond
Mar 13, 2009·Developmental Neurobiology·Beth A HabeckerRichard E Zigmond
May 6, 2016·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Feb 26, 2004·The Journal of Comparative Neurology·Lina M E PetterssonNils Danielsen
Dec 20, 2017·Frontiers in Systems Neuroscience·Beatrice M GirardMargaret A Vizzard
Jul 20, 2018·Journal of Molecular Neuroscience : MN·Thomas J HeppnerMargaret A Vizzard
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