The Effects of Azithromycin in Treatment-Resistant Cough: A Randomized, Double-Blind, Placebo-Controlled Trial

Chest
David HodgsonTim Harrison

Abstract

Chronic cough is a common clinical problem worldwide. Although many patients have underlying precipitating conditions such as asthma, gastroesophageal reflux, or rhinitis, many remain symptomatic despite treating these conditions. New approaches are needed for the treatment of this group of patients. We conducted a randomized, double-blind, placebo-controlled trial to determine whether 250 g of azithromycin three times a week for 8 weeks would affect the Leicester Cough Questionnaire (LCQ) score in 44 patients with treatment-resistant cough. Cough severity on a visual analog scale and bronchial exhaled nitric oxide were measured as secondary outcomes. There was a clinically important improvement in LCQ score with azithromycin (mean change, 2.4; 95% CI, 0.5 to 4.2) but not placebo (mean change, 0.7; 95% CI, -0.6 to 1.9), but the between-group difference was not statistically significant (P = .12). There were no significant between-group differences for any of the secondary outcome measures. Looking at subgroups of responders, there was a large and significant improvement in LCQ score in patients with chronic cough and a concurrent diagnosis of asthma who were treated with azithromycin (mean, 6.19; 95% CI, 4.06 to 8.32). Treatmen...Continue Reading

References

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Citations

Apr 17, 2018·Expert Opinion on Pharmacotherapy·Nicole M RyanSurinder S Birring
Feb 6, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Matthew J MartinTim W Harrison
Jan 19, 2019·The Cochrane Database of Systematic Reviews·Malene Plejdrup HansenChris B Del Mar
Dec 15, 2016·MMW Fortschritte der Medizin·H S Füeßl
Sep 14, 2019·The European Respiratory Journal·Alyn H MoriceAngela Zacharasiewicz
Sep 23, 2020·European Journal of Internal Medicine·Dina ViscaAntonio Spanevello
Dec 3, 2020·ERJ Open Research·Simon D FraserSimon P Hart
May 21, 2021·Annals of the American Thoracic Society·Sabina A GulerManuela Funke-Chambour
Sep 4, 2021·ERJ Open Research·Mathilde DescazeauxLaurent Guilleminault
Nov 23, 2021·The Cochrane Database of Systematic Reviews·Krishna UndelaGiovanni Ferrara

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