The effects of balanced blood component resuscitation and crystalloid administration in pediatric trauma patients requiring transfusion in Afghanistan and Iraq 2002 to 2012

The Journal of Trauma and Acute Care Surgery
Mary J EdwardsDavid W Tuggle

Abstract

Component balanced resuscitation and avoidance of crystalloids in traumatically injured adults requiring massive transfusion are beneficial. Evidence for children is lacking. After institutional review board approval was obtained, the Department of Defense Trauma Database identified 1,311 injured children 14 years or younger requiring transfusion after an injury and admitted to a deployed US military hospital from 2002 to 2012. Logistic regression determined risk factors for high-volume (≥40 mL/kg) or massive (≥70 mL/kg) transfusions. The effects of crystalloid and balanced component resuscitation in the first 24 hours were assessed. Nine hundred seven patients had recorded data sufficient for analysis. Two hundred twenty-four children received high-volume transfusion, and 77 received massive transfusions. Mortality was significantly higher for massive transfusions and high-volume transfusions than others (25% vs. 10% and 19% vs. 9%, respectively). Age of less than 4 years, penetrating injury, and Injury Severity Score (ISS) greater than 15 were associated with high-volume transfusions; an ISS greater than 15 and penetrating injury were associated with massive transfusions. Increased crystalloid administration showed a signific...Continue Reading

References

May 1, 1985·Critical Care Medicine·J R HewsonB W Shragge
May 19, 2009·Anesthesia and Analgesia·Beth H ShazChristopher D Hillyer
Oct 5, 2010·Seminars in Pediatric Surgery·Jeffrey J Dehmer, William T Adamson
Dec 2, 2011·Transfusion·Jeanne E HendricksonCassandra D Josephson
Oct 16, 2012·The Journal of Trauma and Acute Care Surgery·Sara J ChidesterJonathan I Groner
Nov 3, 2012·The Journal of Trauma and Acute Care Surgery·Mary J EdwardsChristopher Coppola
Feb 26, 2013·British Journal of Haematology·Yaser A DiabNaomi L C Luban

❮ Previous
Next ❯

Citations

Jun 12, 2016·Transfusion Medicine Reviews·Oliver Karam, Marisa Tucci
May 10, 2017·The Journal of Trauma and Acute Care Surgery·Jeremy W CannonLucas P Neff
Feb 24, 2018·Current Opinion in Pediatrics·Meghan Gilley, Suzanne Beno
Mar 15, 2018·The Journal of Trauma and Acute Care Surgery·Stephanie F PolitesChristopher R Moir
Aug 31, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Oliver KaramUNKNOWN Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PAL
Jan 11, 2019·The Journal of Trauma and Acute Care Surgery·Reed W KamyszekElisabeth T Tracy
Jul 13, 2019·The Journal of Trauma and Acute Care Surgery·A Francois TrappeyUNKNOWN Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC) Collaborators of the Pediatric Emergency Ca
Feb 12, 2020·The Journal of Trauma and Acute Care Surgery·Colin Howard MurphyHua Shan
Jan 24, 2020·The Journal of Trauma and Acute Care Surgery·Steven G SchauerMatthew A Borgman
May 25, 2020·Transfusion Medicine·Kyle KinslowAdel Elkbuli
May 29, 2018·Pediatric Surgery International·Xiaoming ShiBrandon Propper
Aug 7, 2018·Pediatric Emergency Care·Graeme Maw, Claire Furyk
Apr 17, 2018·Military Medicine·Ryan J KeneallyKevin M Creamer
Aug 17, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Manmeet SehdevJeffry Nahmias
Oct 23, 2020·Transfusion·Andrew C SayceChristine M Leeper
Feb 9, 2021·The Journal of Surgical Research·Nina MbadiweAlisa McQueen
Dec 3, 2020·Frontiers in Pediatrics·Thorsten Haas, Melissa M Cushing
Jul 22, 2019·The American Journal of Emergency Medicine·Steven G SchauerMatthew A Borgman
Nov 5, 2019·The Journal of Surgical Research·Adel ElkbuliDessy Boneva
Aug 28, 2021·The Journal of Trauma and Acute Care Surgery·Jenny StevensDenis Bensard
Jan 7, 2022·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert RussellUNKNOWN Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), the Pediatric Critical Care Blood Rese
Jan 7, 2022·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Marianne E NellisUNKNOWN Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaborati

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.