The Effects of Bazedoxifene on Bone, Glucose, and Lipid Metabolism in Postmenopausal Women With Type 2 Diabetes: An Exploratory Pilot Study

Journal of Clinical Medicine Research
Taishi YoshiiYasuo Terauchi

Abstract

Selective estrogen receptor modulators (SERMs) decrease homocysteine and cross-linking of pentosidine and reduce low-density lipoprotein cholesterol (LDL-C), and they are expected to improve bone quality and atherosclerosis. Therefore, the potential effects of bazedoxifene on bone (bone resorption, bone formation, and bone quality), as well as on glucose and lipid metabolism markers, were examined in Japanese postmenopausal women with type 2 diabetes mellitus (T2DM). Eligible patients received 20 mg of bazedoxifene tablets once daily and were followed up for 12 weeks. Bone resorption markers including tartrate-resistant acid phosphatase 5b (TRACP-5b), bone formation markers and bone quality markers such as homocysteine and serum pentosidine, total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and HbA1c were all measured. Twenty patients completed this study. All bone resorption markers decreased significantly 4 weeks after bazedoxifene treatment. In particular, TRACP-5b decreased significantly at 12 weeks (median percent change: -20.6%), and the minimum significant change (MSC) achievement rate of TRACP-5b was 65%. Bazedoxifene also decreased bone formation markers. However, bazedoxi...Continue Reading

Citations

Jun 30, 2016·Arthritis Research & Therapy·Ya-Ping XiaoLiu Zhang
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Stavroula A PaschouDimitrios G Goulis
Oct 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suriyan PonnusamyRamesh Narayanan
Sep 17, 2019·World Journal of Diabetes·Silvia Costantini, Caterina Conte
Jan 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suriyan PonnusamyRamesh Narayanan

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Methods Mentioned

BETA
X-ray

Software Mentioned

HOLOGIC
SPSS
Statistical Package for the Social Sciences ( SPSS

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