The effects of bee venom acupuncture on the central nervous system and muscle in an animal hSOD1G93A mutant

Toxins
MuDan CaiEun Jin Yang

Abstract

Amyotrophic lateral sclerosis (ALS) is caused by the degeneration of lower and upper motor neurons, leading to muscle paralysis and respiratory failure. However, there is no effective drug or therapy to treat ALS. Complementary and alternative medicine (CAM), including acupuncture, pharmacopuncture, herbal medicine, and massage is popular due to the significant limitations of conventional therapy. Bee venom acupuncture (BVA), also known as one of pharmacopunctures, has been used in Oriental medicine to treat inflammatory diseases. The purpose of this study is to investigate the effect of BVA on the central nervous system (CNS) and muscle in symptomatic hSOD1G93A transgenic mice, an animal model of ALS. Our findings show that BVA at ST36 enhanced motor function and decreased motor neuron death in the spinal cord compared to that observed in hSOD1G93A transgenic mice injected intraperitoneally (i.p.) with BV. Furthermore, BV treatment at ST36 eliminated signaling downstream of inflammatory proteins such as TLR4 in the spinal cords of symptomatic hSOD1G93A transgenic mice. However, i.p. treatment with BV reduced the levels of TNF-α and Bcl-2 expression in the muscle hSOD1G93A transgenic mice. Taken together, our findings suggest t...Continue Reading

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Citations

May 12, 2017·EMBO Molecular Medicine·Sadanori MiyoshiYuji Yamanashi
Nov 26, 2016·International Journal of Molecular Sciences·Edilene S SoaresMaria Alice da Cruz-Höfling
Dec 13, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sung-Jin KimByung-Kwan Seo
Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rim WehbeZiad Fajloun
Oct 1, 2020·Toxins·Ting-Yen Lin, Ching-Liang Hsieh
Jul 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sunjung Park, Eun Jin Yang
Jan 9, 2019·Frontiers in Cellular Neuroscience·Kathleen JordanCassie S Mitchell
Jul 18, 2017·Journal of Acupuncture and Meridian Studies·Raquel Nascimento de SouzaMagda Alves de Medeiros

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Methods Mentioned

BETA
Transgenic

Software Mentioned

Image J
GraphPad Prism
GraphPad

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