The Effects of Beetroot Juice on Blood Pressure, Microvascular Function and Large-Vessel Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Pilot Study in Healthy Older Adults

Nutrients
Tomos JonesAamer Sandoo

Abstract

: Dietary nitrate (NO3-) has been reported to improve endothelial function (EF) and blood pressure (BP). However, most studies only assess large-vessel EF with little research on the microvasculature. Thus, the aim of the present pilot study is to examine NO3- supplementation on microvascular and large-vessel EF and BP. Twenty older adults (63 ± 6 years) were randomized to a beetroot juice (BRJ) or placebo (PLA) group for 28 (±7) days and attended three laboratory visitations. Across visitations, blood pressure, microvascular function and large-vessel EF were assessed by laser Doppler imaging (LDI) with iontophoresis of vasoactive substances and flow-mediated dilatation (FMD), respectively. Plasma NO3-concentrations, BP and the presence of NO3- reducing bacteria were also assessed. Plasma NO3- increased following two weeks of BRJ supplementation (p = 0.04) along with a concomitant decrease in systolic and diastolic BP of approximately -6 mmHg and -4 mmHg, respectively (p = 0.04; p = 0.01, respectively). BP remained unchanged in the PLA group. There were no significant differences in endothelium-dependent or endothelium-independent microvascular responses between groups. FMD increased by 1.5% following two weeks of BRJ (p = 0.04...Continue Reading

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Citations

Jan 5, 2021·Contemporary Clinical Trials Communications·Marissa N BaranauskasStephen J Carter
Dec 30, 2020·Nutrients·George Moschonis, Kalliopi Karatzi
Apr 13, 2021·Journal of Cancer Prevention·Mei Lan Tan, Shahrul Bariyah Sahul Hamid
Jun 24, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth J PekasSong-Young Park
May 27, 2021·Experimental Physiology·Danial T JonesGabriella M K Rossetti
Oct 7, 2021·Nutrition Reviews·Laís de Souza Gouveia MoreiraDenise Mafra

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Methods Mentioned

BETA
scraping
scrapings

Software Mentioned

moorLDI Review
SPSS Statistics
Brachial Analyser

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