PMID: 6108606Jan 1, 1980Paper

The effects of beta-adrenergic receptor blockade on the inhibition of gastric acid secretion, and the release of pancreatic polypeptide by antral distension in healthy subjects

Scandinavian Journal of Gastroenterology
I M SchöönL Olbe

Abstract

In a randomized double-blind study of seven healthy subjects an intravenous injection of metoprolol and propranolol did not change the submaximal gastric acid response to pentagastrin. The inhibition of pentagastrin-stimulated acid secretion by balloon distension of the antrum was unchanged by a preceding intravenous injection of metoprolol or propranolol. The plasma level of pancreatic polypeptide in peripheral venous blood showed a significant rise during antral distension. This rise was unaltered by a preceding injection of metoprolol and slightly depressed by propranolol. We conclude that the inhibitory effect of antral distension on gastric acid secretion in healthy subjects is not mediated by beta 1 or beta 2-adrenergic mechanisms. The reflex release of pancreatic polypeptide by antral distension may possibly involve a weak beta 2-adrenergic component.

References

Jan 1, 1979·Scandinavian Journal of Gastroenterology·T W SchwartzL Olbe
Jan 1, 1978·Scandinavian Journal of Gastroenterology·F Gottrup, J Ornsholt
Mar 1, 1978·The Journal of Clinical Investigation·T W SchwartzF Stadil
Jan 1, 1969·Scandinavian Journal of Gastroenterology·S J Konturek, J Oleksy
Sep 26, 1973·Journal of Chromatography·E Di SalleP L Morselli

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Citations

Nov 15, 1979·Experientia·N D ChristofidesS R Bloom
Jan 1, 1980·Scandinavian Journal of Gastroenterology·I M SchöönL Olbe

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