The effects of beta-aminopropionitrile on colonic anastomosis in rats

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Turker BulutMurat Koser

Abstract

Wound contraction is a clinically important biological process because it frequently results in contractures, strictures, and stenosis. If collagen synthesis could be altered to minimize the contracture, then the outcome could be improved. Lathyrism produces poorly cross-linked collagen in healing anastomosis, keeping a larger portion of the synthesized collagen soluble. Ultimately, the amount of contracting collagen is reduced, lowering the bulk and lessening the contracture. The aim of this study was to observe the effects of a lathyrogen, beta-aminopropionitrile (BAPN), on the healing of colonic anastomosis. Thirty rats were divided into three groups. Colostomy and anastomosis were performed on all rats. Intraperitoneal saline solution (control) and either intraperitoneal (ip) or oral (po) BAPN were administered. The rats were killed 1 week later. Anastomotic healing was assessed by bursting pressure and the hydroxyproline content of the anastomotic tissues. Granulation tissue thickness, number of fibroblasts, inflammatory cells, and growing capillaries in granulation tissue per unit area were determined. Collagen fibril diameters were estimated, and spatial arrangements of fibrils were examined by an electron microscope. Al...Continue Reading

References

Oct 1, 1979·The Journal of Surgical Research·A J AremM Chvapil
Oct 1, 1990·Diseases of the Colon and Rectum·T Hendriks, W J Mastboom
Nov 1, 1990·The Journal of Surgical Research·R C Lee, J A Ping
Feb 1, 1987·Gastroenterology·M F GrahamC O Elson
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A F HaneyJ W Madden
Jul 1, 1967·Clinical Pharmacology and Therapeutics·H R KeiserA Sjoerdsma
Jul 1, 1967·Clinical Pharmacology and Therapeutics·H R Keiser, A Sjoerdsma
Oct 1, 1972·Annals of Surgery·W M DavisE E Peacock
Oct 1, 1966·Biochemical Pharmacology·J RosmusZ Deyl
Jul 1, 1984·The Journal of Surgical Research·W O RichardsA L Moulton
Dec 1, 1983·Diseases of the Colon and Rectum·G H Ballantyne
Oct 1, 1983·Experimental and Molecular Pathology·D L HoffmanM Chvapil
Jan 1, 1983·Experimental Neurology·L L RankinP R Weinstein
Oct 1, 1994·Pathology, Research and Practice·H M Kagan
Jun 1, 1996·Clinical Biochemistry·G K Reddy, C S Enwemeka
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·R G PaulA J Bailey
Jun 1, 1997·The Surgical Clinics of North America·F J Thornton, A Barbul
Jun 1, 1997·The Surgical Clinics of North America·D L Steed
Oct 27, 1997·American Journal of Surgery·H L JosephG R Tobin
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·L I Smith-Mungo, H M Kagan
Apr 29, 1998·The Annals of Otology, Rhinology, and Laryngology·E J DoolinM C Santos
Nov 8, 2001·European Journal of Pharmacology·G M Gilad, V H Gilad
Apr 1, 1996·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·H P Ehrlich, T M Krummel

❮ Previous
Next ❯

Citations

Jul 1, 2008·The Journal of Biological Chemistry·Héctor A LuceroHerbert M Kagan
Nov 1, 2013·Biology of Reproduction·Sunil BalgobinRuth Ann Word
Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Keerthi AtluriJames A Martin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.