The effects of blood pressure lowering on development of cognitive impairment and dementia in patients without apparent prior cerebrovascular disease

The Cochrane Database of Systematic Reviews
B McGuinnessR Bullock

Abstract

Hypertension and cognitive impairment are prevalent in older people. It is known that hypertension is a direct risk factor for vascular dementia and recent studies have suggested hypertension also impacts upon prevalence of Alzheimer's disease. The question is therefore whether treatment of hypertension lowers the rate of cognitive decline. To assess the effects of blood pressure lowering treatments for the prevention of dementia and cognitive decline in patients with hypertension but no history of cerebrovascular disease. The trials were identified through a search of CDCIG's Specialised Register, CENTRAL, MEDLINE, EMBASE, PsycINFO and CINAHL on 27 April 2005. Randomized, double-blind, placebo controlled trials in which pharmacological or non-pharmacological interventions to lower blood pressure were given for at least six months. Two independent reviewers assessed trial quality and extracted data. The following outcomes were assessed: incidence of dementia, cognitive change from baseline, blood pressure level, incidence and severity of side effects and quality of life. Three trials including 12,091 hypertensive subjects were identified. Average age was 72.8 years. Participants were recruited from industrialised countries. Mea...Continue Reading

Citations

Jul 16, 2011·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Avron Spiro, Christopher B Brady
Aug 22, 2009·Neuroepidemiology·Elan D LouisUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Jul 15, 2009·Hypertension·Mika KivimäkiMartin J Shipley
Sep 23, 2010·Vascular Health and Risk Management·Suzanne A LigthartEdo Richard
Dec 29, 2011·Age·Vincenzo SolfrizziUNKNOWN Italian Longitudinal Study on Aging Working Group
Jan 9, 2009·The Journal of Clinical Hypertension·Thomas G Pickering
Oct 31, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José M García SantosGinés Ortega
Oct 1, 2007·Acta Neuropsychiatrica·Dimiter Hadjiev, Petya Mineva
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Bernadette McGuinnessRoger Bullock
Sep 8, 2021·Alzheimer's Research & Therapy·Hákon Valur DanssonUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Oct 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Christopher PattersonChris MacKnight
Jun 27, 2009·Clinics in Geriatric Medicine·Thomas Olabode Obisesan

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