The effects of bone marrow aspirate, bone graft, and collagen composites on fixation of titanium implants

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Hassan BabikerSøren Overgaard

Abstract

Replacement of extensive local bone loss especially in revision joint arthroplasty and spine fusion is a significant clinical challenge. Allograft and autograft have been considered as gold standards for bone replacement. However, there are several disadvantages such as donor site pain, bacterial contamination, and non union as well as the potential risk of disease transmission. Hydroxyapatite and collagen composites (HA/Collagen) have the potential in mimicking and replacing skeletal bones. This study attempted to determine the effects of newly developed HA/Collagen-composites with and without bone marrow aspirate (BMA) on enhancement of bone implant fixation. Titanium alloy implants were inserted into bilateral femoral condyles of eight skeletally mature sheep, four implants per sheep. The implant had a circumferential gap of 2 mm. The gap was filled with: HA/Collagen; HA/Collagen-BMA; autograft or allograft. Allograft was served as the control group. The observation period was 5 weeks. The sheep were euthanized and both femurs were harvested. A push-out mechanical test and histological analysis were performed. No significant differences were seen in the mechanical properties and histomorphometry between autograft and allogra...Continue Reading

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Citations

Apr 9, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Sara Tavassoli HojatiMohammad Atai
Feb 27, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ralf OheimPia Pogoda
Jul 22, 2014·Journal of Biomedical Materials Research. Part a·Ming DingSøren Overgaard
Sep 25, 2014·Acta Cirúrgica Brasileira·Davi Reis CalderoniPaulo Kharmandayan
May 10, 2017·Journal of Tissue Engineering and Regenerative Medicine·Christina M AndreasenSøren Overgaard
Jan 26, 2013·Journal of Tissue Engineering and Regenerative Medicine·Hassan BabikerSøren Overgaard

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