The effects of breathing a helium-oxygen gas mixture on maximal pulmonary ventilation and maximal oxygen consumption during exercise in acute moderate hypobaric hypoxia.

European Journal of Applied Physiology
Takeshi OgawaTakeshi Nishiyasu

Abstract

To test the hypothesis that maximal exercise pulmonary ventilation (VE max) is a limiting factor affecting maximal oxygen uptake (VO2 max) in moderate hypobaric hypoxia (H), we examined the effect of breathing a helium-oxygen gas mixture (He-O(2); 20.9% O(2)), which would reduce air density and would be expected to increase VE max. Fourteen healthy young male subjects performed incremental treadmill running tests to exhaustion in normobaric normoxia (N; sea level) and in H (atmospheric pressure equivalent to 2,500 m above sea level). These exercise tests were carried out under three conditions [H with He-O(2), H with normal air and N] in random order. VO2 max and arterial oxy-hemoglobin saturation (SaO(2)) were, respectively, 15.2, 7.5 and 4.0% higher (all p < 0.05) with He-O(2) than with normal air (VE max, 171.9 ± 16.1 vs. 150.1 ± 16.9 L/min; VO2 max, 52.50 ± 9.13 vs. 48.72 ± 5.35 mL/kg/min; arterial oxyhemoglobin saturation (SaO(2)), 79 ± 3 vs. 76 ± 3%). There was a linear relationship between the increment in VE max and the increment in VO2 max in H (r = 0.77; p < 0.05). When subjects were divided into two groups based on their VO2 max, both groups showed increased VE max and SaO(2) in H with He-O(2), but VO2 max was increa...Continue Reading

References

Sep 1, 1992·Journal of Applied Physiology·B D JohnsonJ A Dempsey
May 1, 1992·Journal of Applied Physiology·E A AaronJ A Dempsey
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·Y OhyabuY Honda
Sep 1, 1989·Journal of Applied Physiology·S R Hopkins, D C McKenzie
Mar 1, 1985·Journal of Applied Physiology·J R Torre-BuenoR E Moon
Apr 1, 1988·Journal of Applied Physiology·J LawlerD Thompson
Aug 1, 1986·International Journal of Sports Medicine·S K PowersR E Beadle
Jan 1, 1971·Journal of Applied Physiology·E Byrne-QuinnR F Grover
Oct 1, 1980·The Journal of Clinical Investigation·S N Mink, L D Wood
Jun 1, 1995·Respiration Physiology·B K EricksonP D Wagner
Feb 1, 1995·International Journal of Sports Medicine·P KoistinenJ Leppäluoto
Feb 1, 1995·Respiration Physiology·G Ferretti, P E di Prampero
Jul 1, 1994·Journal of Applied Physiology·H V ForsterA L Forster
Feb 1, 1993·Journal of Sports Sciences·D Martin, J O'Kroy
Aug 1, 1996·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·M J Buono, R Maly
May 1, 1997·Journal of Applied Physiology·C A HarmsJ A Dempsey
Mar 21, 1998·Medicine and Science in Sports and Exercise·T P GavinJ M Stager
Jun 11, 1998·Journal of Applied Physiology·S R McClaranJ A Dempsey
Mar 6, 1999·Journal of Applied Physiology·R S RichardsonP D Wagner
Jul 25, 2000·Journal of Applied Physiology·C A HarmsJ A Dempsey
Nov 18, 2000·Medicine and Science in Sports and Exercise·P A DerchakR F Chapman
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J A L CalbetB Saltin
Aug 5, 2003·European Journal of Applied Physiology·Henri BenoitChristian Denis
Aug 12, 2003·European Journal of Applied Physiology·Pietro Enrico di Prampero
Jan 6, 2005·Medicine and Science in Sports and Exercise·Xavier WooronsJean-Paul Richalet
Nov 29, 2005·European Journal of Applied Physiology·Jon Peter Wehrlin, Jostein Hallén
Mar 22, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chantal A VellaRobert A Robergs
Feb 17, 2007·Respiratory Physiology & Neurobiology·H-C Holmberg, José A L Calbet
May 31, 2007·European Journal of Applied Physiology·Pascal MollardJean-Paul Richalet
Jun 30, 2007·Journal of Applied Physiology·Jose A L CalbetBengt Saltin
Jun 27, 2009·High Altitude Medicine & Biology·José A L Calbet, Carsten Lundby

❮ Previous
Next ❯

Citations

Jul 6, 2014·European Journal of Applied Physiology·Guido Ferretti
Aug 28, 2012·Respiratory Physiology & Neurobiology·Christoph SiebenmannCarsten Lundby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Applied Physiology
Andrew W SubudhiRobert C Roach
International Journal of Sports Medicine
P MognoniA Veicsteinas
Respiratory Physiology & Neurobiology
Craig D Steinback, Marc J Poulin
Journal of Science and Medicine in Sport
Jordan A Guenette, A William Sheel
© 2021 Meta ULC. All rights reserved