The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study

American Journal of Physical Medicine & Rehabilitation
John WhyteH Branch Coslett

Abstract

To evaluate the effects of bromocriptine on a variety of aspects of attention, ranging from laboratory-based impairment measures to caregiver ratings and work productivity, in individuals after traumatic brain injury. Twelve adults with moderate to severe traumatic brain injury and attention complaints in the postacute phase of recovery were enrolled in a 6-wk double-blind, placebo-controlled, crossover study of bromocriptine, titrated to a dose of 5 mg twice a day. A wide range of attentional measures was administered weekly, including computerized and paper-and-pencil tests of attention, videotaped records of individual work in a distracting environment, real-time observational scoring of attentiveness in a classroom environment, and caregiver and clinician ratings of attentiveness. Data from these 12 participants were used to identify attentional dimensions suggestive of a treatment effect for independent replication. The effects of bromocriptine on 13 previously identified attentional factors and 13 individual performance scores were assessed via the Wilcoxon signed ranks test, using a relaxed probability cutoff of 0.20 to select those to be studied in a larger replication sample. Only two factor scores and one individual s...Continue Reading

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Citations

Sep 16, 2010·Current Treatment Options in Neurology·Alison N CernichPatricia B Ryan
Aug 7, 2012·Current Treatment Options in Neurology·Hal S Wortzel, David B Arciniegas
Dec 12, 2012·Translational Stroke Research·Coleen M Atkins
Sep 29, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Thomas W McAllisterAndrew J Saykin
Jan 24, 2016·Brain Research·Saurabha BhatnagarRoss Zafonte
Jun 4, 2016·Brain : a Journal of Neurology·Peter O JenkinsDavid J Sharp
Mar 23, 2017·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Sunil MunakomiBijoy Mohan Kumar
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Alexandra N GarciaAnthony E Kline
Nov 23, 2019·Neuropsychological Rehabilitation·Nancy D ChiaravallotiJohn DeLuca
Mar 1, 2018·Arquivos de neuro-psiquiatria·Renato AnghinahJéssica Natuline Ianof
Sep 15, 2018·Molecular Psychiatry·Jennifer L McGuireRobert E McCullumsmith
Jan 14, 2021·The Annals of Pharmacotherapy·Sumie Kakehi, Danielle M Tompkins

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