PMID: 43367Dec 1, 1979

The effects of bromocriptine on pre-synaptic and post-synaptic alpha-adrenoceptors in the mouse vas deferens

The Journal of Pharmacy and Pharmacology
A Gibson, M Samini


Noradrenaline (NA) and dopamine (DA) contracted the mouse vas deferens and reduced the responses to low frequency nerve stimulation (0.1 Hz). The relative potencies of antagonists suggested that these effects were due to stimulation of post-synaptic and pre-synaptic alpha-adrenoceptors respectively. Bromocriptine produced a non-competitive antagonism of contractile responses to NA (pD2' = 7.6) and DA (pD2' = 8.0) but had no effect on responses to carbachol. Bromocriptine also reduced single twitch responses of the vas to low frequency field stimulation (0.1 Hz), but did not affect stimulation at higher frequencies (1--20 Hz). Yohimbine selectively and rapidly reversed the inhibiting effects of bromocriptine on single twitches, although they could not easily be reversed by washing. Bromocriptine produced a yohimbine-reversible reduction in the stimulated overflow of tritium from vasa previously loaded with 3H--NA. Thus the mouse vas deferens does not appear to contain specific DA receptors and the results suggest that bromocriptine acts as a pre-synaptic alpha-adrenoceptor agonist and post-synaptic alpha-adrenoceptor antagonist in this tissue.


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Jan 1, 1981·General Pharmacology·S PatelS C Verma
Jan 1, 1982·General Pharmacology·H MirandaE Fernandez
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Jun 11, 1997·European Journal of Pharmacology·T Furukawa, H Morishita
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·K FukuzakiR Nagata
Nov 30, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M SaminiA R Dehpour
Jan 1, 1992·Fundamental & Clinical Pharmacology·J RoquebertP Demichel
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Oct 1, 1989·British Journal of Pharmacology·C Kennedy, G Henderson
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Apr 1, 1982·The Journal of Pharmacy and Pharmacology·A BadiaF Jané


Jun 1, 1977·The Journal of Pharmacy and Pharmacology·R R RuffoloP N Patil
Aug 1, 1977·European Journal of Pharmacology·F G van den Brink, E J Lien
Jan 1, 1977·Journal of Neural Transmission·J Y LewM Goldstein
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·A C DolphinB Testa
Jan 1, 1978·British Journal of Pharmacology·I MarshallN B Shepperson
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Mar 1, 1975·British Journal of Pharmacology·M E Jones, T L Spriggs
Dec 1, 1975·European Journal of Pharmacology·K StarkeT Endo
Dec 1, 1977·British Journal of Pharmacology·D A JenkinsP A Nasmyth
Apr 1, 1979·British Journal of Pharmacology·T Dalton
Oct 1, 1977·British Journal of Pharmacology·C Bell, G Matalanis
Mar 1, 1973·The Journal of Pharmacy and Pharmacology·P N PatilS Hetey
Apr 1, 1971·Acta Physiologica Scandinavica·G Swedin
Dec 1, 1973·British Journal of Pharmacology·J Hughes
Apr 1, 1965·The Journal of Pharmacy and Pharmacology· VAN ROSSUMJ
Aug 1, 1976·British Journal of Clinical Pharmacology·J K GreenacreJ L Reid

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Yohimbin Spiegel
Mouse Vas Deferens
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Antagonist Muscle Action
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Adrenergic alpha-Agonists

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