The effects of cadmium on succinate and NADH-linked substrate oxidations in rat hepatic mitochondria

Journal of Applied Toxicology : JAT
I CameronM Wood

Abstract

Low concentrations of cadmium (3.3-40 microM) inhibited State 3 NADH-linked respiration in rat hepatic mitochondria, but failed to release oligomycin (1 microgram) inhibited State 3 respiration, or to significantly change the State 4 rate. In the presence of succinate, 40 microM cadmium inhibited State 3 respiration by 89%, while concentrations between 3.3 and 13.3 microM stimulated State 4 respiration. Higher concentrations caused marked inhibition. In the presence of succinate, cadmium released oligomycin inhibited State 3 respiration. Cadmium (0.001-1.0 mM) did not stimulate mitochondrial ATPase activity or inhibit ferricyanide reduction, but stimulated NAD+ linked mitochondrial dehydrogenase activities and NADH oxidation. These results indicate that cadmium interacts with either the NADH dehydrogenase complex or other NADH-dependent enzymes and not solely by an uncoupling action.

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Citations

Apr 3, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ann CuypersKaren Smeets
Jan 30, 2013·Critical Reviews in Biochemistry and Molecular Biology·Young-Mi Go, Dean P Jones
Jun 11, 2008·Neurotoxicology·Ana Paula RigonRodrigo B Leal
Apr 25, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Anna V IvaninaInna M Sokolova
May 27, 2008·Toxicology and Applied Pharmacology·Elena A BelyaevaLech Wojtczak
Apr 26, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sergey M KorotkovIrina V Brailovskaya
Jun 11, 2020·Antioxidants·Jacopo J V BrancaMatteo Becatti
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Frank ThévenodMichael D Garrick
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Jacopo Junio Valerio BrancaMatteo Becatti

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