The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

Toxicological Research
Yoojin KwakJaesook Roh

Abstract

This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals. The long bones of immature rats exposed to caffeine were significantly shorter and lighter than those of control animals along with decreased bone minerals. However, there was no difference in the length or weight of the long bones in young adult rats exposed to caffeine. Exposure to caffeine reduced the size and absolute weight of the testes significantly in immature animals in comparison to control animals, but not in young adult animals exposed to caffeine. In contrast, the adrenal glands were significantly heavier in caffeine-fed young adult rats in comparison to control animals, but not in caffeine-fed immature rats. Our results clearly show that the negative effec...Continue Reading

References

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Citations

Oct 3, 2019·Recent Patents on Drug Delivery & Formulation·Nada A HelalMohamed I Nounou
Apr 3, 2021·Life Sciences·Fernanda Batista de SouzaEliziária Cardoso Dos Santos

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