The effects of calcitonin on plasma calcium levels and bone metabolism in the fresh water teleost Channa punctatus

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Dola MukherjeeDilip Mukherjee

Abstract

Administration of salmon calcitonin (sCT) caused significant reduction in total and ultrafiltrable plasma calcium content in the plasma of a fresh water female teleost Channa punctatus. A time-bound analysis on the effect of sCT showed a highly significant short duration reduction in total and ultrafiltrable plasma calcium content in fish kept in normal tap water and low-calcium water and a moderate hypocalcemia in fish kept in high-calcium water. Sexually immature adult fish showed a greater response than the sexually mature ones. Using tartrate-resistant acid phosphatase (TRACP) and alkaline phosphatase (ALP) activities in plasma and hydroxyproline (HYP) excretion in urine, the effect of sCT on the inhibition of bone calcium resorption were examined. In both sexually mature and immature adult fish, kept in normal tap water, sCT significantly suppressed TRACP and ALP activities in plasma and excretion of HYP in urine within 2-6 h with a maximum at 4 h after injection. Salmon CT treatment to sexually immature adult fish caused significant increase in skeletal bone calcium concentration. Taken together, all this information indicates that CT in a fresh water female teleost is an effective regulator of plasma calcium levels, and ...Continue Reading

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Citations

Oct 11, 2011·BMC Genomics·Florbela A VieiraDeborah M Power
Jan 1, 2011·Journal of Basic and Clinical Physiology and Pharmacology·Ajai Kumar SrivastavSunil Kumar Srivastav
May 13, 2014·General and Comparative Endocrinology·Rute MartinsDeborah M Power
May 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anne-Gaëlle LafontPung-Pung Hwang
Jun 19, 2013·General and Comparative Endocrinology·Florbela A VieiraD M Power
Jun 22, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·T N LoewenW G Anderson
Feb 22, 2017·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Jyotsna Murthy, Devi Manisha

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