The Effects of Calorie Restriction and Exercise on Age-Related Alterations in Corpus Cavernosum

Frontiers in Physiology
Caglar MacitGoksel Sener

Abstract

Aging is an important risk factor for erectile dysfunction (ED). Both calorie restriction (CR) and physical exercise (PE) have been established as a non-medical method for the improvement of detrimental changes in aging. It is well documented that both CR and PE influence on sympathetic and parasympathetic systems; however, there are few studies on non-adrenergic non-cholinergic pathways. This study aims to investigate the NO-mediated mechanisms of CR and PE on corpus cavernosum in aged rats. 3 and 15 month-old rats were divided into five experimental groups: young rats fed ad libitum (Y-C), aged rats fed ad libitum (O-S), aged rats with CR (O-CR), aged rats with PE (O-PE), and aged rats with CR and PE (O-CR-PE). CR was applied to animals as a 40% reduction of daily food intake for 6 weeks. PE was moderate swimming at 30 min at 3 days/week. The effects of CR and PE were evaluated by histologic, biologic, and in-vitro tissue bath studies. The outcomes in CR and PE groups (characterized by decreased nitrosative damage together with increased antioxidant capacity) were improved in comparison to the O-S. Apoptotic biomarkers were also lower and both endothelial and smooth muscle cell' functions were preserved too. There was no stat...Continue Reading

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Citations

Oct 4, 2020·International Journal of Impotence Research·Zatiye Ayça Çevikelli-YakutGöksel Şener

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Methods Mentioned

BETA
chip
ELISA
PCA
Protein Assay
electrophoresis
Assay
MDA

Software Mentioned

SPSS

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