PMID: 2117691Jan 1, 1990Paper

The effects of carbidopa on the metabolism of 6-[18F]fluoro-L-dopa in rats, monkeys and humans

Life Sciences
W P MelegaJ R Barrio

Abstract

The effects of carbidopa on the peripheral metabolism of 6-[18F]fluoro-L-DOPA (FDOPA) were characterized in the rat, monkey and human along with its effects on cerebral FDOPA metabolism in the rat. After carbidopa pretreatment, FDOPA plasma metabolite profiles in all three species revealed extensive metabolism of FDOPA to 3-0-methyl-6-[18F]-fluoro-L-DOPA (3-OMFD). In humans, there were significant increases in FDOPA plasma levels for 30 min and in 3-OMFD levels for 120 min after FDOPA administration. 6-[18F]Fluorodopamine sulfate (FDA-sulfate) and [18F]fluoro-homovanillic acid (FHVA) levels were decreased, while at all times, free 6-[18F]-fluorodopamine (FDA) and 6-[18F]-3-4 dihydroxy-phenylacetic acid (FDOPAC) were not detected. In rat brain, the FDOPA metabolite profile at 30 min was significantly altered by carbidopa pretreatment; increases were noted for striatum FDA (700%) and 3-OMFD (230%), and for cerebellum FDOPA (370%) and 3-OMFD (300%). Thus, carbidopa pretreatment increased FDOPA plasma levels for a given FDOPA dose and essentially restricted peripheral FDOPA metabolism to 3-OMFD formation. The increase in FDOPA bioavailability to the brain resulted in greater selective FDA accumulation in striatum. As such, carbidop...Continue Reading

Citations

Dec 1, 1990·Journal of Neuroscience Research·J R BarrioM E Phelps
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C A McLellanR M Cohen
Dec 7, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K L Leenders
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J R BarrioM E Phelps
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T IshikawaD Eidelberg
Mar 8, 2012·Nuclear Medicine Communications·Ferdinando CalabriaOrazio Schillaci
Aug 1, 1991·British Journal of Clinical Pharmacology·V J CunninghamT Jones
Jun 9, 1998·Annals of the New York Academy of Sciences·P CummingA Gjedde
Jul 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·M GuttmanA Gjedde
Oct 19, 2004·Journal of Neuroscience Methods·Marina E Emborg
Feb 1, 1992·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·A LuxenR Wagner
Aug 1, 1997·Biochemical Pharmacology·J R BarrioM E Phelps
Jan 18, 2015·Bioorganic & Medicinal Chemistry·Masakatsu KanazawaHideo Tsukada
Jul 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K Shoghi-JadidJ R Barrio
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P CummingA Gjedde
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S C HuangM E Phelps
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W P MelegaJ R Barrio
Aug 18, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne S BerryWilliam J Jagust
Jul 23, 1998·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R T Allison, D Bryant
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Pascual-LeoneJ P Keenan
Jun 1, 1996·Physics in Medicine and Biology·L Wahl, C Nahmias
Jan 10, 2012·Clinical Nuclear Medicine·Michael HentschelIngo Brink
Oct 1, 1994·Seminars in Nuclear Medicine·G B SahaR T Go

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