The effects of carotid body hypocapnia on ventilation in goats

Respiration Physiology
L DaristotleG E Bisgard

Abstract

This study was designed to examine the influence of carotid body (CB) hypocapnia on ventilation by selectively perfusing the CB through an extracorporeal circuit in 19 goats. When PcbCO2 was decreased from normocapnic levels in 14 awake goats (delta PcbCO2 = 10.9 Torr), PaCO2 increased 5.6 Torr (P less than 0.05) and VE decreased 24% (P less than 0.001) (mean values). The ventilatory sensitivity to inspired CO2 was not changed by CB hypocapnia in 5 of these goats, but the response was shifted to the right. During CB hypocapnia, ventilatory instability, including apnea, was observed in 4 of 14 goats; this irregular breathing continued at elevated levels of PaCO2. In 5 anesthetized goats, CB hypocapnia (delta PcbCO2 = 18.0 Torr) decreased VE by 70% in the intact state, but produced no significant ventilatory depression after CB denervation. We conclude that CB hypocapnia depresses ventilation in both awake and anesthetized goats mostly through CB chemoreceptor effects, and suggest that this hypoventilation may predispose to ventilatory instability in some animals.

References

Jun 1, 1989·Respiration Physiology·L Daristotle, G E Bisgard
Dec 1, 1988·Respiration Physiology·M J EngwallG E Bisgard
Jun 1, 1971·Respiration Physiology·R S Fitzgerald, D C Parks
Apr 1, 1969·Respiration Physiology·J Flórez, H L Borison
Dec 1, 1967·Respiration Physiology·R E DuttonA Fenner
Nov 1, 1982·Circulation Research·M J BrunnerA A Shoukas

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Citations

Feb 1, 1996·Respiration Physiology·M S Badr, A Kawak
Mar 29, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Pauline L EntinRichard E Rawson
Jan 15, 2002·Respiration Physiology·Guy LongobardoNeil S Cherniack
Sep 29, 1999·Progress in Neurobiology·E Nattie
Oct 19, 2002·Respiratory Physiology & Neurobiology·Aihua Li, Eugene Nattie
Oct 30, 2009·Journal of Cellular and Molecular Medicine·Kfir SharabiYosef Gruenbaum
Dec 2, 2004·Experimental Physiology·Jerome A Dempsey
Sep 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J A Dempsey, C A Smith
Sep 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·H V Forster, L G Pan
May 8, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin J Cummings, Peter B Frappell
Jan 1, 1997·Journal of Applied Physiology·M R DwinellG E Bisgard

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