The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury.

Drug and Chemical Toxicology
Abdolhamid EsmaeeliMohammad Seyedabadi

Abstract

The β-adrenoceptor blockers may have anti-oxidant properties or induce β-arrestin recruitment beyond classical desensitization of receptor/G protein coupling, offering potential therapeutic benefits. Here, we investigated the effects of carvedilol, metoprolol and propranolol in an animal model of cisplatin-induced nephrotoxicity. Rats received the β-blockers (3 or 12 mg/kg/day) with or without cisplatin, and kidney function was investigated using renal scintigraphy, histopathology, and serum variables. Metoprolol and propranolol as well as low-dose carvedilol did not alter kidney function, per se. Meanwhile, high-dose carvedilol reduced renal accumulation of Technetium-99m (99mTc)-labeled dimercaptosuccinic acid (99mTc-DMSA) without significant effect on other variables. Furthermore, low-dose carvedilol prevented cisplatin-induced reduction of tracer uptake, but high-dose of this drug aggravated the situation. In this regard, both low and high -doses of carvedilol significantly inhibited cisplatin effects on kidney histology, BUN and creatinine levels. Also, high-dose propranolol inhibited cisplatin adverse effects on radiotracer uptake, histological manifestations, BUN and creatinine levels, while metoprolol failed to cause a ...Continue Reading

References

Jan 1, 1988·European Journal of Nuclear Medicine·A M PetersI Gordon
Oct 23, 1997·Journal of the American Society of Nephrology : JASN·D Sheikh-HamadZ Jalali
Feb 24, 2001·Fundamental & Clinical Pharmacology·G SenerM Keyer-Uysa
May 2, 2002·Anti-cancer Drugs·M I Koukourakis
May 20, 2004·American Journal of Physiology. Renal Physiology·Istvan AranyRobert L Safirstein
Dec 14, 2004·Journal of the American Society of Nephrology : JASN·Peter BenoehrJorg T Hartmann
Jul 7, 2005·Basic & Clinical Pharmacology & Toxicology·Samira Saleh, Ebtehal El-Demerdash
Mar 3, 2006·Bioorganic & Medicinal Chemistry·Ana GomesEduarda Fernandes
Aug 19, 2007·The American Journal of the Medical Sciences·Xin YaoKenneth Nugent
Oct 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·James W WislerRobert J Lefkowitz
Feb 5, 2008·Toxicology·Yolanda I ChirinoJosé Pedraza-Chaverri
Feb 15, 2008·Kidney International·N Pabla, Z Dong
Jan 20, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T A AjithN P Sudheesh
Sep 24, 2009·Mitochondrion·M A Carvalho RodriguesA C Santos
Aug 21, 2010·Journal of Nuclear Medicine Technology·Hamid JavadiMajid Assadi
Nov 16, 2010·Journal of Molecular and Cellular Cardiology·Nabila NoorHoward A Rockman
Mar 3, 2012·Archives of Toxicology·Neife Aparecida Guinaim dos SantosAntonio Cardozo dos Santos
Apr 24, 2012·Journal of Signal Transduction·Hilary CassidyTara McMorrow
Apr 1, 2014·Current Opinion in Pharmacology·Vaidehi J ThanawalaRichard Bond
Jan 16, 2016·Annual Review of Medicine·Anna Zuk, Joseph V Bonventre
Mar 10, 2017·American Journal of Physiology. Renal Physiology·Yandao WangChen Yu
Jun 9, 2017·Nephron·Eoghainín Ó hAinmhire, Benjamin D Humphreys
Jun 20, 2017·Pharmacological Reviews·Yuri K Peterson, Louis M Luttrell
Jan 5, 2018·Expert Opinion on Therapeutic Targets·Mohammad SeyedabadiJean-Eric Ghia
Jan 18, 2018·Physiological Genomics·Michael HultströmSofia Jönsson
Oct 23, 2020·Pharmacological Reports : PR·Abdolhamid EsmaeeliMohammad Seyedabadi

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Citations

Feb 10, 2021·Biomolecules·Mohammad SeyedabadiVsevolod V Gurevich
Mar 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh MirzaeiMasoud Najafi
Aug 17, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Rasha M S M MohamedDalia M Abd El Motteleb

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