Dec 1, 1977

The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma

The Journal of Urology
E J SanfordC W Bardin

Abstract

Selective adrenal vein catheterization was done on intact and castrated men with prostatic carcinoma. Adrenal to peripheral venous testosterone gradients were observed in all patients, indicating adrenal production of this hormone. No compensatory adrenal production of testosterone was noted during a 17-month period after orchiectomy. The data suggest that the human adrenal in castrates produces testosterone, which may explain why adrenal ablation can offer palliation in some patients with prostatic carcinoma.

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Mentioned in this Paper

Catheterization
Adrenal Glands
Sterotate
Adrenal Gland Neoplasms
Prostatism
Castration
Palliative Surgery
Malignant Neoplasm of Prostate

About this Paper

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