The effects of catecholamine and related compounds on the adenyl cyclase system in the epidermis.

The British Journal of Dermatology
K YoshikawaV Levine

Abstract

The effect of various hormones and drugs on the adenyl cyclase system of pig and human epidermal slices was studied in vitro. Adrenaline and isoproterenol in the presence of theophylline increased the epidermal cyclic AMP level 20-fold in 5 min. Noradrenaline also stimulated cyclic AMP accumulation but to a much lesser degree. The adrenaline stimulation was marked even in the absence of the phosphodiesterase inhibitor, theophylline. Theophylline potentiated the effect of adrenaline at the concentration of 2-10 mM although theophylline alone did not elevate the cyclic AMP level significantly. The Km for adrenaline stimulation of the adenyl cyclase system of pig epidermis was 7-7 X 10(-7) M. A beta-adrenergic antagonist, propranolol, markedly inhibited the adrenaline stimulation while alpha-antagonists, phentolamine or priscoline, showed little effect. The results are in accord with the view that the epidermis possesses an active adenyl cyclase system with beta-adrenergic receptors.

References

Mar 1, 1975·The British Journal of Dermatology·K YoshikawaV Levine
Mar 1, 1975·The British Journal of Dermatology·M M MuiK M Halprin
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Sep 1, 1970·The British Journal of Dermatology·P D Mier, E Urselmann
Sep 1, 1971·The Journal of Investigative Dermatology·S Kondo, K Adachi
Sep 15, 1971·Nature: New Biology·G O BronstadI Oye
Jul 1, 1972·The Journal of Investigative Dermatology·S L HsiaK M Halprin

❮ Previous
Next ❯

Citations

Jan 1, 1990·Archives of Dermatological Research·H ElayanM G Ziegler
Jan 1, 1981·Archives of Dermatological Research·E J EssmanE Valderrama
Jan 1, 1987·Archives of Dermatological Research·M TsutsuiT Kanzaki
Jan 1, 1985·Archives of Dermatological Research·A Ohkawara, H Iizuka
Sep 10, 1985·European Journal of Pharmacology·H G Johnston, R J Summers
Jan 1, 1980·Pharmacology & Therapeutics·C L Marcelo, J J Voorhees
Jan 1, 1979·Journal of Periodontology·M F GrowerJ A Stow
Jun 1, 1976·The British Journal of Dermatology·K YoshikawaV Levine
Aug 1, 1987·The Journal of Dermatology·M Watanabe, H Iizuka
Jun 1, 1980·The British Journal of Dermatology·H IizukaY Miura
Jul 1, 1982·The British Journal of Dermatology·O Holian, R Kumar
Nov 1, 1982·The British Journal of Dermatology·K AdachiV Levine
May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Bruna R SouzaAndréa M A Costa
Jun 1, 1988·International Journal of Dermatology·J Fransson, H Hammar
Apr 1, 1980·The Journal of Experimental Zoology·M K Dunlap, D J Donaldson
Aug 1, 1983·The Journal of Dermatology·H IshizawaA Ohkawara
Apr 1, 1981·The Journal of Dermatology·T AoyagiY Miura
Dec 1, 1982·The Journal of Dermatology·T AoyagiY Miura
Jan 1, 1980·Biochemical Pharmacology·E A Duell
Oct 22, 1976·Biochimica Et Biophysica Acta·H IizukaV Levine
Jan 1, 1981·The Journal of Investigative Dermatology·T AoyagiC W Woodyard
Mar 1, 1980·The Journal of Investigative Dermatology·J R TaylorV Levine
Jul 1, 1983·The Journal of Investigative Dermatology·T AoyagiY Miura
Sep 1, 1983·The Journal of Investigative Dermatology·J TakedaC Woodyard
Mar 1, 1977·The Journal of Investigative Dermatology·N J Lowe, R B Stoughton
Nov 1, 1977·The Journal of Investigative Dermatology·H IizukaV Levine
Mar 1, 1978·The Journal of Investigative Dermatology·H IizukaV Levine
Apr 1, 1981·The Journal of Investigative Dermatology·J J DiGiovannaK M Halprin
Jun 1, 1981·The Journal of Investigative Dermatology·H IizukaY Miura
Nov 1, 1981·The Journal of Investigative Dermatology·K YoshikawaK Adachi
Feb 1, 1983·The Journal of Investigative Dermatology·O NemotoC Woodyard
Jun 1, 1983·The Journal of Investigative Dermatology·H Iizuka, A Ohkawara
Mar 1, 1985·The Journal of Investigative Dermatology·T AoyagiY Miura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.