The effects of central and peripheral angiotensin on hypertension and nociception in rats

Pharmacology, Biochemistry, and Behavior
R J Irvine, J M White

Abstract

Spontaneously hypertensive rats (SHRs) rats have been reported to have decreased sensitivity to pain, but as yet a mechanism has not been identified. This study investigated the effects of subcutaneous and intracerebroventricular (ICV) infusions of angiotensin II on blood pressure, locomotor activity, and tailflick and hot plate latencies in the Wistar-Kyoto (WKY) and outbred Wistar rat. Peripheral but not central administration of angiotensin II (567 micrograms/kg/day) increased hot plate latencies in WKY and Wistar rats to a level equivalent to that observed in the SHR. Peripheral administration of norepinephrine (50 and 100 mg/kg/day) to WKYs increased blood pressure but had no effect on hotplate latency. ICV administration of losartan (1 & 3 mg/kg/day) to SHRs had no effect on blood pressure or nociception. The results indicate that angiotensin II has a role in the altered pain perception observed in the SHR and that its site of action is peripheral.

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Citations

May 5, 2005·Brain Research. Molecular Brain Research·Patrícia Aline BoerJosé Antonio Rocha Gontijo
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·A MalpassF Bochner
Apr 15, 2014·Current Pain and Headache Reports·Erling Tronvik, Lars Jacob Stovner
Jun 1, 2014·Neuropeptides·Anjana BaliAmteshwar Singh Jaggi
Dec 17, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Anjana BaliAmteshwar Singh Jaggi

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