The effects of central injections of calcitonin gene-related peptide on fear-related behavior

Neurobiology of Learning and Memory
L H Poore, Fred J Helmstetter

Abstract

Calcitonin gene-related peptide (CGRP) has been localized in several regions of the rat brain that are known to be important for the expression of fear responses. Some evidence suggests that CGRP may act as a neurotransmitter at synapses that are believed to be important for aversive learning. In the present study, male rats were prepared with intracerebroventricular cannulae and injected with CGRP during different phases of training and testing when a distinctive environment was paired with foot shock. When injected prior to training, CGRP directly evoked fear-related behavior and postshock freezing. When pretreated with CGRP and exposed to the shock-associated environment 24 h after training rats again showed an enhanced fear response. These results support the idea that this peptide functions as a neurotransmitter at central synapses which are important for the expression of fear.

Citations

Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kelly S SinkMichael Davis
Dec 1, 2001·Stress : the International Journal on the Biology of Stress·R Landgraf
Apr 27, 2002·The Journal of Comparative Neurology·Fernando Martínez-GarcíaEnrique Lanuza
Aug 8, 2015·Scientific Reports·Narumi Hashikawa-HobaraNaoya Hashikawa
Jun 3, 2015·British Journal of Clinical Pharmacology·Andrew F Russo
Feb 27, 2001·Neurobiology of Learning and Memory·L H Kocorowski, F J Helmstetter
Sep 2, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Narumi Hashikawa-HobaraNaoya Hashikawa
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·K L HullS Harvey

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