The effects of cerebellar stimulation on the stretch reflex in the spastic monkey

Brain : a Journal of Neurology
T J EbnerA B Schwartz

Abstract

The effects of stimulating the cerebellar surface on abnormal segmental reflexes were examined in monkeys rendered spastic by either bilateral or unilateral decortication of areas 1, 2, 3, 4 and 6. Rectified, integrated electromyographic (EMG) activity from the biceps and triceps as well as the torque were recorded and averaged during successive flexion-extension movements of the arm produced by a displacement controlled torque motor. Two movement paradigms were employed. The first consisted of a ramp and hold paradigm with an initial rapid flexion of the forearm, a subsequent two second period during which the arm position was held constant, and a rapid extension returning the limb to the initial position. In the second paradigm, the forearm was modulated sinusoidally at several different frequencies. Cerebellar stimulating electrodes were placed over the paravermal region bilaterally. Different frequencies (10 to 300 HZ) and different charge densities (1.5 to 10 microC/cm2) were used in each animal. In each experimental trial short periods of cerebellar stimulation (10 to 30 minutes) were interspersed between control periods. As observed in some types of clinical spasticity, flexion or extension of the extremity was capable o...Continue Reading

Citations

Jan 7, 1998·Trends in Neurosciences·J R Wolpaw
May 21, 2014·Anesthesia and Analgesia·Viviane S Hambrecht-WiedbuschRalph Lydic
Jul 1, 1989·IEEE Transactions on Bio-medical Engineering·A StefanovskaR Acimović-Janezic
Mar 29, 2018·Journal of Neurophysiology·Mark L Latash
May 1, 1989·Pacing and Clinical Electrophysiology : PACE·C HershlerC Zoghaib

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