The Effects of Cerebral Vasospasm on Cerebral Blood Flow and the Effects of Induced Hypertension: A Mathematical Modelling Study

Interventional Neurology
Pervinder BhogalPablo J Blanco

Abstract

Induced hypertension has been used to promote cerebral blood flow under vasospastic conditions although there is no randomised clinical trial to support its use. We sought to mathematically model the effects of vasospasm on the cerebral blood flow and the effects of induced hypertension. The Anatomically Detailed Arterial Network (ADAN) model is employed as the anatomical substrate in which the cerebral blood flow is simulated as part of the simulation of the whole body arterial circulation. The pressure drop across the spastic vessel is modelled by inserting a specific constriction model within the corresponding vessel in the ADAN model. We altered the degree of vasospasm, the length of the vasospastic segment, the location of the vasospasm, the pressure (baseline mean arterial pressure [MAP] 90 mm Hg, hypertension MAP 120 mm Hg, hypotension), and the presence of collateral supply. Larger decreases in cerebral flow were seen for diffuse spasm and more severe vasospasm. The presence of collateral supply could maintain cerebral blood flow, but only if the vasospasm did not occur distal to the collateral. Induced hypertension caused an increase in blood flow in all scenarios, but did not normalise blood flow even in the presence ...Continue Reading

References

Dec 1, 1992·Journal of Neurosurgery·D M Swift, R A Solomon
Dec 1, 1992·Journal of Biomechanics·N StergiopulosT R Rogge
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·I A AwadF C Williams
Sep 1, 1973·Journal of Biomechanics·D F Young, F Y Tsai
Sep 25, 2003·Lancet Neurology·Jon SenNeil Kitchen
Feb 24, 2010·Critical Care : the Official Journal of the Critical Care Forum·Jan W DankbaarIrene C van der Schaaf
May 31, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Philippe ReymondNikos Stergiopulos
Sep 11, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael R LevittKathleen R Fink
Dec 11, 2013·Nature Reviews. Neurology·R Loch Macdonald
Jan 17, 2014·International Journal for Numerical Methods in Biomedical Engineering·Lucas O Müller, Eleuterio F Toro
Apr 1, 2014·Biomechanics and Modeling in Mechanobiology·Pablo J BlancoRaúl A Feijóo
Oct 28, 2014·IEEE Transactions on Bio-medical Engineering·Pablo BlancoRaul Feijoo
Dec 24, 2015·International Journal for Numerical Methods in Biomedical Engineering·Lucas O MüllerRaúl A Feijóo
Apr 12, 2016·Journal of Biomechanics·P J BlancoR A Feijóo
Jul 16, 2016·Journal of Neurointerventional Surgery·Pervinder BhogalMichael Söderman
Jun 13, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Pervinder BhogalHegoda Ld Makalanda
Nov 22, 2017·Stroke; a Journal of Cerebral Circulation·Celine S GathierUNKNOWN HIMALAIA Study Group

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Citations

Jul 23, 2021·International Journal for Numerical Methods in Biomedical Engineering·Xiancheng ZhangHao Liu

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