The effects of chloroquine on the electrocardiogram and heart rate in anaesthetized dogs

Clinical Physiology
O A Sofola

Abstract

The effects of intravenous administration of chloroquine on the electrocardiogram (ECG) and heart rate were studied in anaesthetized dogs. Prolongation of the PR interval on the ECG and bradycardia occurred from a dose of 4 mg kg-1. Prolongation of the QRS interval occurred from 6 mg kg-1. Pacing the heart at a constant rate or administration of atropine had no effect on the cardiac changes observed during chloroquine administration. Administration of propranolol potentiated the effects of chloroquine on the ECG intervals and heart rate, whereas adrenaline opposed these effects. It is suggested that prolongation of the ECG intervals is not secondary to the reduction in heart rate, whilst beta-adrenergic blockade renders the heart more vulnerable to the actions of chloroquine.

References

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Citations

Sep 30, 1995·Lancet·J L ClemessyF J Baud
Nov 1, 1996·Human & Experimental Toxicology·N A BuckleyD L O'Connell
Dec 1, 1990·European Journal of Epidemiology·C FarinaG Carosi
Jul 1, 1996·Critical Care Medicine·J L ClemessyF J Baud
Jan 7, 1988·The New England Journal of Medicine·B RiouF J Baud
Mar 27, 1990·European Journal of Pharmacology·L TonaT M Brody

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