Abstract
Male mice selected for genetic differences in ethanol-induced sleep time, thereby designated long sleep (LS) an short sleep (SS), were treated with the Lieber-DeCarli liquid diet for 25 days. This chronic ethanol treatment produced an increase in liver/body weight and kidney/body weight in SS mice only. In addition, chronic ethanol treatment produced significant increases in both LS and SS treated mice in in vivo ethanol elimination, hepatic cytochromes P-450 and B5, NADPH cytochrome c reductase and hepatic and renal 7-ethoxycoumarin O-de-ethylase activity. Genotypic differences were observed in the magnitude of response of microsomal ethanol oxidation per mg of microsomal protein (SS greater than LS). Further, control LS and SS mice possessed substantially different activity of renal 7-ethoxycoumarin O-de-ethylase. Both lines exhibited similar induced renal 7-ethoxycoumarin O-de-ethylase activity after chronic ethanol ingestion. Ethanol binding spectra produced when ethanol was added to hepatic microsomes were examined using double reciprocal plots. Chronic ethanol ingestion produced genotypically related (LS greater than SS) increases in the absorbance change maximum per mg of microsomal protein. No significant changes in the...Continue Reading
References
Feb 20, 1975·The New England Journal of Medicine·M A KorstenC S Lieber
Jan 1, 1971·Biochemical Pharmacology·E RubinR Kuntzman
Jan 19, 1968·Science·J H Mendelson
Mar 1, 1967·The Journal of Nutrition·L M DeCarli, C S Lieber
Jun 1, 1973·The Biochemical Journal·D L CintiS Orrenius
Citations
Jan 1, 1985·Psychopharmacology·T D McIntyre, H P Alpern
Jan 1, 1983·Psychopharmacology·T C HowertonA C Collins
Oct 15, 1989·Biochemical Pharmacology·S W BigelowD W Nebert
Aug 1, 1982·Pharmacology, Biochemistry, and Behavior·M F O'ConnorA C Collins
Mar 1, 1985·Alcohol·W R ProctorT V Dunwiddie
Aug 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·D LangH Eason
Jan 1, 1990·Journal of Psychoactive Drugs·R C Johnson, C T Nagoshi
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·D M GilliamA C Collins
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T ZyssetF R Simon
Jan 1, 1987·Pharmacology & Toxicology·O Tokola
Apr 21, 1987·Brain Research·A J ScheetzE Fifková
Dec 1, 1986·Alcoholism, Clinical and Experimental Research·C DelpéroJ Boyer
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·D M Gilliam, A C Collins
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·D M Gilliam, A C Collins
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·T ZyssetF R Simon
Aug 1, 1994·Acta Psychiatrica Scandinavica·F HohagenM Berger
May 22, 2016·Journal of Plastic Surgery and Hand Surgery·Tamer YavasMehmet Bayramicli