The effects of chronic high dose androgen or estrogen treatment on the human prostate [corrected

The Journal of Clinical Endocrinology and Metabolism
B JinD J Handelsman

Abstract

Prostate development and disease are androgen dependent. However, the nature of hormonal effects on the prostate of healthy young men is not clear. We, therefore, measured prostate size in males chronically exposed to high doses of androgens (AS; habitual anabolic steroid abusers; n = 15) or estrogens (E; male to female transsexuals; n = 11) and compared the results with those in age-matched healthy eugonadal men without known prostate disorders. Prostate size was measured by planimetric ultrasound as cross-sectional areas and maximal dimensions in three orthogonal dimensions with a 7.5-megahertz B-mode sector scanner biplane in a transrectal transducer at 2.5 mm steps from the base to the apex of prostate. Total prostate volume (TPV) was reconstructed from planimetric sections, central prostate volume (CPV) was calculated by the ellipsoidal formula from the appropriate three maximum dimensions, and peripheral prostate volume was determined by the difference between TPV and CPV. Compared with age-matched controls, TPV was normal (-2%) in AS (P = 0.752) and reduced by 31% in E (P = 0.002), whereas CPV was increased by 20% in AS (P = 0.002) and reduced by 46% in E (P = 0.002), and the ratio of CPV/peripheral prostate volume was i...Continue Reading

Citations

Oct 6, 2007·Postgraduate Medical Journal·Nicola TugnetTim R Terry
Jan 11, 2014·Asian Journal of Andrology·Lori A Cooper, Stephanie T Page
Jun 14, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Jean-Jacques KalachJean André
May 31, 2011·Differentiation; Research in Biological Diversity·Tristan M Nicholson, William A Ricke
Sep 23, 2009·Hormones and Behavior·Gen KanayamaHarrison G Pope
May 9, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Annette KuhnMartin Birkhäuser
Aug 11, 2007·Annales d'endocrinologie·M Duclos
Jan 8, 2008·Biochemical and Biophysical Research Communications·Hyun Joo LeeKeesook Lee
Aug 19, 2007·Annales d'endocrinologie·V Corman, J-J Legros
Aug 21, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·B P JonesJ R Smith
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·B JinD J Handelsman
Apr 25, 2001·Clinical Endocrinology·B JinD J Handelsman

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