The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits

Neurourology and Urodynamics
Masaki YoshidaMasashi Shiomi

Abstract

Lower urinary tract symptoms (LUTS) are common in the aging population. LUTS cause profoundly negative impacts on their quality of life. Pathophysiology of LUTS is multifactorial, and recently, bladder ischemia and metabolic syndrome have been suggested as etiological factors. To evaluate chronic hyperlipidemia on bladder function, we examined the functional and histological changes of the bladder in myocardial infarction-prone Watanabe Heritable Hyperlipidemic (WHHLMI) rabbits. 20- to 24-month-old WHHLMI rabbits and age- and sex-matched control rabbits were prepared. Bladder functions were evaluated using cystometrograms and functional experiments with isolated bladder specimens. Histological studies of bladder and internal iliac arteries were performed with hematoxylin and eosin staining. The bladder was also stained immunohistochemically with mouse monoclonal S-100 antibodies and sheep polyclonal calcitonin gene-related peptide (CGRP) antibodies. In cystometric examination, WHHLMI rabbits showed significantly shorter micturition interval, smaller voided volume with non-voiding contractions, and lower micturition pressure, as compared to control. The functional experiments showed that carbachol- and electrical field stimulati...Continue Reading

References

Oct 19, 1999·The Journal of Urology·K M AzadzoiM B Siroky
May 10, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Masashi ShiomiJianglin Fan
Nov 17, 2005·BJU International·Yukio HommaUNKNOWN Neurogenic Bladder Society Committee
Apr 29, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Koichi MasunagaShoichi Ueda
Feb 3, 2007·Urology·Hwancheol SonJae-Seung Paick
Mar 12, 2008·Pathophysiology of Haemostasis and Thrombosis·Stephen G WorthleyJuan J Badimon
Apr 25, 2008·The Journal of Urology·Wei-Chia LeeShih-Wei Lee
Nov 19, 2008·Molecular Interventions·David R Robinson, G F Gebhart

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Citations

Sep 23, 2014·International Urology and Nephrology·Pradeep TyagiNaoki Yoshimura
Dec 3, 2013·Neurourology and Urodynamics·Osamu YamaguchiKarl-Erik Andersson
Apr 23, 2011·The Journal of Urology·Hikaru HashitaniHikaru Suzuki
Mar 1, 2012·Lower Urinary Tract Symptoms·En MengYao-Chi Chuang
Apr 5, 2012·Neurourology and Urodynamics·Motoaki SaitoKeisuke Satoh
Dec 8, 2011·BJU International·Seiya InoueAtsushi Takenaka
Sep 10, 2011·Neurourology and Urodynamics·Masanori NomiyaNorio Takahashi
Mar 1, 2012·Lower Urinary Tract Symptoms·Hwancheol SonWon Hee Park
Dec 8, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Seiji Matsumoto, Hidehiro Kakizaki
Aug 7, 2012·British Journal of Pharmacology·Hikaru HashitaniKeiichiro Nakamura
Sep 1, 2014·Lower Urinary Tract Symptoms·Masaki Yoshida, Osamu Yamaguchi
Jun 17, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Shogo ShimizuMotoaki Saito
Oct 24, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Masanori NomiyaOsamu Yamaguchi
Oct 26, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Sibel BayrakAyşen Erdem
Nov 5, 2013·The Journal of Urology·Masanori NomiyaKarl-Erik Andersson
Oct 7, 2017·Neurourology and Urodynamics·Robin LütolfJ Todd Purves
Jun 3, 2014·Therapeutic Advances in Urology·Karl-Erik AnderssonOsamu Yamaguchi
Aug 15, 2018·Neurourology and Urodynamics·Todd LadanchukKate H Moore
Mar 27, 2013·Scandinavian Journal of Urology·Hakki UzunOrhan Ünal Zorba
Oct 3, 2012·The Medical Journal of Australia·Gary A WittertAndre Araujo
Dec 6, 2017·Expert Review of Clinical Pharmacology·Seyedeh-Sanam Ladi-SeyedianAbdol-Mohammad Kajbafzadeh
Jul 28, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaKenji Maeda
Jul 28, 2021·Life Sciences·Shogo ShimizuMotoaki Saito

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