The effects of chronic hypoxia on renal function in the rat

The Journal of Physiology
M NeylonE J Johns

Abstract

1. Studies were performed on rats that had been made chronically hypoxic (CH rats) in a normoxic chamber at 12% O2 for 3-5 weeks. Under Saffan anaesthesia, respiratory and cardiovascular variables, renal haemodynamics and renal function were recorded while the rats spontaneously breathed 12% O2 followed by a switch to air breathing for 20 min. Plasma renin activity was assessed by radioimmunoassay of angiotensin I. Plasma atrial natiruetic peptide (ANP) was indirectly assessed by measurement of cyclic GMP in urine. 2. When breathing 12% O2, CH rats showed hyperventilation and raised haematocrit (52%) relative to normoxic (N) rats. But arterial pressure (ABP), renal blood flow (RBF), renal vascular conductance (RVC), mean right atrial pressure (mRAtP), urine flow, glomerular filtration rate (GFR) and absolute sodium excretion (UNaV) were comparable to those recorded in N rats breathing air. Urinary cGMP was 40% greater than in N rats, but plasma renin activity was not significantly greater in CH than in N rats. 3. Air breathing in CH rats induced hypoventilation, a 12% increase in ABP, no change in mRAtP, RBF or GFR, but increases of 75 and 100% in urine flow and UNaV, respectively. Neither urinary cGMP nor plasma renin activity...Continue Reading

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Citations

Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kunitoshi IsekiShuichi Takishita
May 1, 2015·International Urology and Nephrology·Vivian Bertoni XavierYvoty Alves Dos Santos Sens
Mar 17, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J A ClarkeE M Hennessy
Oct 18, 2002·Microscopy Research and Technique·Waltke R PauldingMaria F Czyzyk-Krzeska
Aug 9, 2020·Frontiers in Physiology·Lisa M PalubiskiJulie O'Neill
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T L O'Donaughy, B R Walker
Nov 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Chhinder P SodhiAtul Sahai

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